基本信息 产品详情 公司简介 推荐产品
网站主页 化工产品目录 生物化工 抑制剂 神经信号通路(Neuronal Signaling) GluR 拮抗剂 MPEP MPEP
  • aladdin 阿拉丁 M408882 MPEP 96206-92-7 10mM in DMSO

aladdin 阿拉丁 M408882 MPEP 96206-92-7 10mM in DMSO

MPEP
96206-92-7
622.90 1ml 起订
上海 更新日期:2024-10-31

上海阿拉丁生化科技股份有限公司

VIP13年
联系人:阿拉丁客服
电话:400-400-6206333拨打
手机:18521732826 拨打
邮箱:market@aladdin-e.com

产品详情:

中文名称:
MPEP
英文名称:
MPEP
CAS号:
96206-92-7
品牌:
阿拉丁
产地:
上海
保存条件:
-80℃储存
纯度规格:
10mM in DMSO
产品类别:
药靶配体 药靶配体
分子式:
C14H11N
分子量:
193.24
运输条件:
超低温冰袋运输
产品规格:
1ml
货号:
M408882
是否进口:

中文名:MPEP

英文名:MPEP

英文别名:2-methyl-6-(2-phenylethynyl)pyridine

纯度:10mM in DMSO

货号:M408882

包装:1ml

Cas号:96206-92-7

存储温度:-80℃储存

产品介绍:

Information

MPEP is a selectivemGlu5receptor antagonist withIC50of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
In vitro

MPEP has no appreciable agonist or antagonist activity at the closely related recombinant human mGlu1b receptor expressed in CHO-K1 cells or a purinoreceptor endogenously expressed in L(tk-) cells up to concentrations of 100 μM. Furthermore, MPEP shows no appreciable agonist or antagonist activity in cAMP accumulation or [35S]-GTPγS binding assays at the recombinant human group II and III metabotropic receptors (human mGlu2, -3, -4a, -6, -7b, -8a) as well as the human NMDA (NMDAR1A/2A, -1A/2B), rat AMPA (GluR3) and human kainate (GluR6) receptor subtypes. In slices of rat neonatal hippocampus, striatum, and cortex but not cerebellum, MPEP inhibits DHPG-stimulated PI hydrolysis with IC50 of 8.0 nM, 20.5 nM, and 17.9 nM, respectively. MPEP positively modulates the hmGluR4 in a recombinant expression system, and the effect of MPEP is fully dependent on the activation of the orthosteric agonist L-AP4.

In vivo

When microiontophoretically applied into the brain of rats, MPEP reduces DHPG-induced excitations but not the excitations induced by AMPA. Following intravenous administration, MPEP produces a dose-dependent inhibition of DHPG-induced but not AMPA-induced excitations with a rapid onset of action. Oral administration of MPEP also exhibits excellent anti-hyperalgesic activity in the Complete Freund\'s Adjuvant and turpentine models of inflammatory pain. MPEP (1-30 mg/kg) induces anxiolytic-like effects in the conflict drinking test and the elevated plus-maze test in rats as well as in the four-plate test in mice. MPEP (1-20 mg/kg) shortens the immobility time in a tail suspension test in mice, but it is inactive in the behavioural despair test in rats. MPEP has no effect on locomotor activity or motor coordination. MPEP significantly reduces fmr1 but not wild-type center square entries and duration. In open field tests, MPEP reduces fmr1tm1Cgr center field behavior to one indistinguishable from wild-type. MPEP produces a significant reduction of total locomotor activity in three of four groups tested, at both 10 mg/kg and 30 mg/kg.
Cell Data

cell lines:SKOV-3 cells

Concentrations:

Incubation Time:

Powder Purity:≥99%

查看阿拉丁官网此产品相关对应页面:https://www.aladdin-e.com/zh_cn/M408882.html


2-methyl-6-(2-phenylethynyl)pyridine

公司简介

上海阿拉丁生化科技股份有限公司是A股上市公司((股票代码:688179),专注于科研试剂的研发、生产和销售,已陆续建立多个工厂和研发中心。作为领军企业,阿拉丁始终坚持质量第一,连续13年被评为“最受欢迎试剂品牌”。 阿拉丁目前常备库存试剂产品品种超过7万种,SKU总数超过46万,产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域,是国内少数化学试剂到生物试剂全面发展的国产试剂品牌,产品同步发布在我们国内(www.aladdin-e.com)和海外(www.aladdinsci.com)电商平台。

成立日期 (16年)
注册资本 10093.34万人民币
员工人数 500人以上
年营业额 ¥ 1亿以上
经营模式 工厂,试剂
主营行业 生物化工,生物化工,化学试剂,化学试剂

MPEP相关厂家报价

内容声明
拨打电话 立即询价