aladdin 阿拉丁 B414485 BDTX-189 2414572-47-5 98%

中文名：BDTX-189

英文名：BDTX-189

纯度：Moligand™，≥98%

货号：B414485

Cas号：2414572-47-5

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

BDTX-189 is a potent and selective inhibitor of allostericEGFRandHER2oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2,BLKandRIPK2, reapectively. BDTX-189 exhibits anticancer activity.

Targets

EGFR (Cell-free assay); HER2 (Cell-free assay); RIPK2 (Cell-free assay); BLK (Cell-free assay) 0.2 nM(Kd); 0.76 nM(Kd); 1.2 nM(Kd); 13 nM(Kd)

In vitro

BDTX-189 is a potent, selective, irreversible active site inhibitor of the ERBB allosteric mutant oncogene family. BDTX-189 achieves a superior selectivity profile in cell-based assays.

In vivo

BDTX-189 is differentiated by potent, sustained inactivation of multiple allosteric ERBB mutants in vivo. BDTX-189 achieves dose-dependent regression of allosteric HER2 and EGFR tumors at well-tolerated doses.

Cell Research(from reference)

Cell lines：A431 cells, H292 cells 

Incubation Time：0-24 h 

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