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网站主页 化工产品目录 生物化工 抑制剂 表观遗传学(Epigenetics) HDAC 抑制剂 恩替诺特 Entinostat (MS-275,SNDX-275)
  • 209783-80-2Entinostat (MS-275,SNDX-275)

209783-80-2Entinostat (MS-275,SNDX-275)

Entinostat (MS-275,SNDX-275)
209783-80-2
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上海 更新日期:2024-12-25

上海一研生物科技有限公司

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产品详情:

中文名称:
Entinostat (MS-275,SNDX-275)
英文名称:
Entinostat (MS-275,SNDX-275)
CAS号:
209783-80-2
品牌:
一研
保存条件:
Store at -20°C
产品类别:
抑制剂
Cas:
209783-80-2

产品属性:

产品名称

规格

CAS

型号

Entinostat (MS-275,SNDX-275)

10mM (in 1mL DMSO) 10mg 50mg 100mg

209783-80-2

EY-Y0165360

Cas No.209783-80-2

别名 MS-275,SNDX-275, MS 275, MS-27-275, SNDX275, Histone Deacetylase Inhibitor I, MS27-275

化学名 pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate

分子式 C21H20N4O3

Entinostat (MS-275,SNDX-275).png

分子量 376.4

溶解度 18.8mg/mL in DMSO, 7.4 mg/mL in EtOH with ultrasonic

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
Entinostat (also known as MS-275 or SNDX-275), a derivative of 2-aminophenyl benzamides, is a potent and orally-available inhibitor of histone deacetylases (HDACs), a family of enzymes associated with a variety of well-characterized cellular oncogenes and tumor suppressors, that potently inhibits class I HDACs, including HDAC1, HDAC3 and HDAC8, with values of 50% inhibition concentration IC50 of 0.368 μM, 0.501 μM and 63.4 μM respectively. Entinostat has been widely investigated for the treatment of cancer, in which results have shown the in vitro anti-proliferative activity of entinostat in a wide range of human cancer cell lines, including breast, colon, lung, myeloma, ovary, pancreas, prostate and leukemia.

Reference

Hess-Stumpp H, Bracker TU, Henderson D, Politz O. MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent. Int J Biochem Cell Biol. 2007;39(7-8):1388-405. Epub 2007 Feb 16.

Hess-Stumpp H. Histone deacetylase inhibitors and cancer: from cell biology to the clinic. Eur J Cell Biol. 2005 Mar;84(2-3):109-21.


209783-80-2;C21H20N4O3;Entinostat (MS-275,S;

公司简介

上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业,公司自成立以来,秉承""全心全意服务于科研工作者""的企业理念,立足生物科技领域,运用生物技术和科研试剂,发展现代生物科技,为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品,服务生物科技领域的科学研究人员。 公司具有对普通货物、冷藏及冷冻仓库的存储、包装及运输能力。 公司将始终坚持信誉立业、以人为本、质量保证、诚信服务的宗旨,不断拼搏,开拓进取,与各界朋友携手共创美好未来。

成立日期 (11年)
注册资本 100
员工人数 50-100人
年营业额 ¥ 100万以内
经营模式 工厂,试剂
主营行业 生化试剂,抗体,细胞培养,分子生物学,免疫安全

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