57-88-5Cholesterol

产品属性：

Cas No.57-88-5

别名 N/A

化学名 (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

分子式 C27H46O

分子量 386.65

溶解度 <3.87mg/mL in DMSO

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

Cholesterol is the major sterol in mammals, and its importance in fundamental cellular processes is becoming more appreciated. IC50 value:Target:In vitro: GT1-7 hypothalamic cells subjected to cholesterol depletion in vitro produced 20-31% reductions in cellular cholesterol content, similar to the decrease in cholesterol synthesis observed in diabetes [1].In vivo:

References:

[1]. Laverdy OG, et al. Effects of glycemic control upon serum lipids and lipid transfers to HDL in patients with type 2 diabetes mellitus: novel findings in unesterified cholesterol status. Experimental and Clinical Endocrinology & Diabetes, 2015, 123(4):232-239

[2]. Sandy Huey-Jen Hsu, et al. Validation of the Estimation of Low-density LipoproteinCholesterol by the Modified Friedewald Equation in EthnicChinese Adults Living in Taiwan. Internal Medicine, 54: 2291-2297, 2015

[3]. Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14.