SCH-28080,76081-98-6
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
产品详情:
| 产品编号 | S4443 |
| 品牌 | Sigma |
| 测定 | ≥98% (HPLC) |
| 颜色 | white to light tan |
| 形式 | solid |
| 相容性 | for use with ABI 7700 |
| 分子量 | 277.32 |
| 溶解性 | DMSO: soluble >10 mg/mL H2O: insoluble |
| 储存温度 | −20°C |
| 质量水平 | 100 |
| MDL编号 | MFCD00834620 |
| PubChem化学物质编号 | 24278810 |
别名
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
应用
SCH-28080 was used to treat zebrafish embryos to study the role of H+/K+-ATPase in establishment of left-right axis during development.
生化/生理作用
SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.
公司简介
| 成立日期 | (20年) |
| 注册资本 | 600.0万美元 |
| 员工人数 | 100-500人 |
| 年营业额 | ￥ 1亿以上 |
| 经营模式 | 贸易,试剂,定制,服务 |
| 主营行业 | 分析化学,材料化学,生物化工,化学试剂,催化剂 |
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