基本属性 生物活性靶点体外研究体内研究 用途与合成方法 MSDS 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 价格(试剂级) 供应商 供应信息 相关产品

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

英文名称:2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
CAS号:76081-98-6
分子式:C17H15N3O
分子量:277.32
EINECS号:
Mol文件:76081-98-6.mol
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 结构式

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 性质

密度 1.16±0.1 g/cm3(Predicted)
储存条件 -20°C
溶解度 DMSO:>10 mg/mL
形态 固体
酸度系数(pKa) 5.85±0.10(Predicted)
颜色 白色至浅棕褐色

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 用途与合成方法

SCH28080 是一种可逆的,K+ 竞争性的胃 H,K-ATPase 抑制剂,Ki 值 为 0.12 μM。SCH28080 在体内是有效的酸分泌抑制剂,具有抗溃疡作用。

Ki: 0.12 μM ((H + /K + )-ATPase)

SCH28080 competitively inhibits the K + -stimulated hydrolysis of ATP, with a K i of 0.12 μM .
SCH28080 inhibits histamine-induced [14C] aminopyrine uptake into isolated rabbit parietal cells with an IC 50 of 0.029 μM.
SCH28080 causes a dose-dependent reduction in cell viability with IC 50 values of 22.9 µM and 15.3 µM after 2 h and 24 h treatments, respectively, and cell viability was below 10% at 100 µM already after 2 h treatment.
SCH28080 induces apoptosis and is cytotoxic at higher doses.
SCH28080 inhibits insulin secretion by activation of IK ATP and inhibition of L-type voltage-gated Ca 2+ channels, reduces cell viability and dose-dependently induces apoptosis/necrosis.

Cell Viability Assay

Cell Line: INS-1E cell
Concentration: 3.1 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM
Incubation Time: 2 hours, 24 hours
Result: Caused a dose-dependent reduction in cell viability.

SCH28080 (20 mg/kg; i.p.) inhibits gastric ulcers induced by pylorusligation in rats.

Animal Model: Male Wistar rat (280-350 g), the Shay rat model
Dosage: 20 mg/kg
Administration: Intraperitoneal injection
Result: Showed 91% inhibition on gastric ulcers induced by pylorusligation in rats.

安全信息

安全说明22-24/25
WGK Germany3

MSDS信息

语言:English
提供商:SigmaAldrich

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-103261 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 76081-98-6 1mg 400
2024-11-08 HY-103261 5 mg 1100

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE供应商 更多

武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
英文名称:SCH 28080;2-Methyl-8-(phenylMethoxy)iMidazo[1,2-a]pyridine-3-acetonitrile
CAS:76081-98-6
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话:021-61415566 800-8193336
产品介绍:
英文名称:SCH-28080
CAS:76081-98-6
纯度:>=98% (HPLC), solid
包装信息:10MG
备注:S4443-10MG
上海楼岚生物科技有限公司
联系电话:021-52996696,15000506266 15000506266
产品介绍:
英文名称:SCH28080
CAS:76081-98-6
纯度:98% HPLC
包装信息:5mg,10mg,50mg,100mg,1g,5g
上海超岚化工科技中心
联系电话:QQ:65489617 15618227136
产品介绍:
英文名称:SCH 28080
CAS:76081-98-6
纯度:98%
包装信息:5MG;10MG;50MG;100MG,1G,5G,100G
上海源溪生物科技有限公司
联系电话:021-58447131 13564518121
产品介绍:
英文名称:SCH-28080
CAS:76081-98-6
纯度:98% HPLC
包装信息:100mg,250mg,1g

最新发布供应信息

化合物 SCH28080|T16865|TargetMol
TargetMol中国(陶术生物) 2024-09-29
aladdin 阿拉丁 S286840 SCH 28080,H +,K + -ATPase抑制剂 76081-98-6 98%
上海阿拉丁生化科技股份有限公司 2024-08-16

"2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE"相关产品信息