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ChemicalBook CAS数据库列表 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

生物活性靶点体外研究体内研究 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 试剂级价格

CAS号:76081-98-6
英文名:2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
中文名:2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
CBNumber:CB4281209
分子式:C17H15N3O
分子量:277.32
MOL File:76081-98-6.mol

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE化学性质

密度 :1.16±0.1 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :DMSO: >10 mg/mL, soluble
形态 :solid
酸度系数(pKa) :5.85±0.10(Predicted)
颜色 :white to light tan

安全信息

安全说明 :22-24/25
WGK Germany :3

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE性质、用途与生产工艺

生物活性 SCH28080 是一种可逆的，K+ 竞争性的胃 H,K-ATPase 抑制剂，Ki 值为 0.12 μM。SCH28080 在体内是有效的酸分泌抑制剂，具有抗溃疡作用。
靶点

Ki: 0.12 μM ((H ⁺ /K ⁺ )-ATPase)

体外研究

SCH28080 competitively inhibits the K ⁺ -stimulated hydrolysis of ATP, with a K _i of 0.12 μM .
SCH28080 inhibits histamine-induced ^[14C] aminopyrine uptake into isolated rabbit parietal cells with an IC ₅₀ of 0.029 μM.
SCH28080 causes a dose-dependent reduction in cell viability with IC ₅₀ values of 22.9 µM and 15.3 µM after 2 h and 24 h treatments, respectively, and cell viability was below 10% at 100 µM already after 2 h treatment.
SCH28080 induces apoptosis and is cytotoxic at higher doses.
SCH28080 inhibits insulin secretion by activation of IK ATP and inhibition of L-type voltage-gated Ca ²⁺ channels, reduces cell viability and dose-dependently induces apoptosis/necrosis.

Cell Viability Assay

Cell Line:	INS-1E cell
Concentration:	3.1 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM
Incubation Time:	2 hours, 24 hours
Result:	Caused a dose-dependent reduction in cell viability.

体内研究

SCH28080 (20 mg/kg; i.p.) inhibits gastric ulcers induced by pylorusligation in rats.

Animal Model:	Male Wistar rat (280-350 g), the Shay rat model
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection
Result:	Showed 91% inhibition on gastric ulcers induced by pylorusligation in rats.