137-08-6Calcium D-Panthotenate

产品属性：

Cas No.137-08-6

别名

化学名

分子式 C18H32CaN2O10

分子量 476.53

溶解度 Soluble in DMSO

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Target: N/A

IC50: N/A

Calcium D-Panthotenate, also named vitamin B5 Calcium, is a water-soluble vitamin for many animals [1, 2]. Pantothenic acid participates in a number of intermediary metabolic reactions as a component of coenzyme A (CoA). It has been reported that pantothenic acid exhibits radioprotective and antioxidative effects and pantothenic acid has the potential to protect against cell damage produced by reactive oxygen species [3].

In vitro: Pantothenic acid (1 mM) increased biosynthesis of glutathione by boosting cell energetic in Jurkat cells [3]. In addition, pantothenic acid (1 mM) protected against oxidative damage and apoptosis in Ehrlich ascites tumour cells [4].

In vivo: Pantothenic acid (200 mg/kg, intraperitoneal injections) completely blocked valproic acid-induced neural tube defects and the decreases in c-Myb and Pim-1 protein expression in CD-1 mice [1]. Moreover, Calcium D-pantothenate (3.39-10.54 mg/kg, diets) increased the intestinal enzymes activities and docosahexaenoic acid (DHA) levels [2].

References:

1. Dawson JE, Raymond AM, Winn LM. Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. Toxicol Appl Pharmacol. 2006;211(2):124-32.

2. Qian Y, Li XF, Zhang DD, Cai DS, Tian HY, Liu WB. Effects of dietary pantothenic acid on growth, intestinal function, anti-oxidative status and fatty acids synthesis of juvenile blunt snout bream Megalobrama amblycephala. PLoS One. 2015;10(3):e0119518.

3. Slyshenkov VS, Dymkowska D, Wojtczak L. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Lett. 2004;569(1-3):169-72.

4. Wojtczak L, Slyshenkov VS. Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals--the role of glutathione. Biofactors. 2003;17(1-4):61-73.