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  • 58970-76-6Bestatin

58970-76-6Bestatin

Bestatin
58970-76-6
询价 1盒 起订
上海 更新日期:2024-12-25

上海一研生物科技有限公司

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产品详情:

中文名称:
Bestatin
英文名称:
Bestatin
CAS号:
58970-76-6
品牌:
一研
保存条件:
Store at -20°C
产品类别:
抑制剂
Cas:
58970-76-6

产品属性:

产品名称

规格

CAS

型号

Bestatin

5mg 10mg 25mg 100mg

58970-76-6

EY-Y0163943

Cas No.58970-76-6

别名 Ubenimex,Bestatin

化学名 (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid

分子式 C16H24N2O4

Bestatin.png

分子量 308.37

溶解度 12.34mg/mL in DMSO

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
Ubenimex(Bestatin) is a specific inhibitor of aminopeptidase B and leucine aminopeptidase. It did not show any inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin or thermolysin. Bestatin at 100 pg/ml showed no antibacterial and no antifungal activities. It has low toxicity with no death after intraperitoneal injection of 300 mg/kg to mice1.

Bestatin isolated from the culture filtrate of Streptomyces olivoreticuli MD976-C72. The structure of bestatin was elucidated to be (2S, 3R)-3-amino-2-hydroxy-4- phenylbutanoyll-(S)-leucine3, 4. Bestatin itself was not hydrolyzed by either of the enzymes, when bestatin was incubated as substrate, L-leucine was not detected by thin-layer chromatography.

Unlike the case of orthophenanthroline, the inhibitory activity of bestatin on aminopeptidase B was not reversed by addition of zinc ion. Bestatin has a pair of adjacent amino and hydroxyl groups, which shows metal-complexing activity5-7. If the inhibitory activity of bestatin is attributable to five-membered chelate ring formation by a pair of adjacent amino and hydroxyl groups of bestatin and a metal ion of the enzyme, the isomers having erythro AHPA, which is difficult to form a chelate ring, are expected not to show inhibitory activity. However, the isomers having erythro-AHPA or (2S, 3S)-AHPA showed marked inhibitory activity. Bestatin and its active isomers are effective due to a mechanism other than a chelating action at the active center8.


58970-76-6;C16H24N2O4;Bestatin;

公司简介

上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业,公司自成立以来,秉承""全心全意服务于科研工作者""的企业理念,立足生物科技领域,运用生物技术和科研试剂,发展现代生物科技,为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品,服务生物科技领域的科学研究人员。 公司具有对普通货物、冷藏及冷冻仓库的存储、包装及运输能力。 公司将始终坚持信誉立业、以人为本、质量保证、诚信服务的宗旨,不断拼搏,开拓进取,与各界朋友携手共创美好未来。

成立日期 (11年)
注册资本 100
员工人数 50-100人
年营业额 ¥ 100万以内
经营模式 工厂,试剂
主营行业 生化试剂,抗体,细胞培养,分子生物学,免疫安全

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