Venetoclax维奈妥拉

Venetoclax
1257044-40-8

询价 25mg 起订

200mg 起订

500mg 起订

北京更新日期：2023-03-10

北京百奥创新科技有限公司

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产品详情:

中文名称：: 维奈妥拉

英文名称：: Venetoclax

CAS号：: 1257044-40-8

品牌：: MEDKOO

产地：: 国外

保存条件：: 低温保存

纯度规格：: >98%

产品类别：: 普通产品

Name: Venetoclax (ABT199)
CAS#: 1257044-40-8
Chemical Formula: C45H50ClN7O7S
Exact Mass: 867.3181
Molecular Weight: 868.44
Elemental Analysis: C, 62.24; H, 5.80; Cl, 4.08; N, 11.29; O, 12.90; S, 3.69

Description: Venetoclax, also known as ABT-199 or GDC0199, is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells.

Synonym: ABT199; ABT-199; ABT 199; GDC0199; GDC0199; GDC 0199; RG7601; RG7601; RG 7601. Venetoclax; Venclexta;

IUPAC/Chemical Name: 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide

InChi Key: LQBVNQSMGBZMKD-UHFFFAOYSA-N

InChi Code: InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)

SMILES Code: O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

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维奈妥拉;Venetoclax;1257044-40-8;

公司简介

北京百奥创新科技有限公司是一家专注于生命科学的科技企业，由在国内科研试剂领域有着丰富从业经验的技术团队和管理团队组建而成，专营进口生物试剂，科学仪器，实验消耗品等。公司与诸多国外品牌签下代理，RD、Abcam、CST、Genetex、Biolegend、ebioscience、polypure、polyplus、Bethyl、Novus等，能为广大科研用户提供数万种试剂、仪器和实验消耗品。公司将不断把上优质的产品引入国内市场，满足客户的需求，公司也将紧跟生命科学的发展，为广大科研工作者探索生命科学的奥秘奉献绵薄之力！

成立日期	(10年)
注册资本	100.000000万人民币
员工人数	50-100人
年营业额	￥ 500万-1000万
经营模式	贸易,工厂,试剂,定制,服务
主营行业	中间体,催化剂及助剂,生物化工,化学试剂,仪器耗材