864249-60-5

Description: AMG-548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα. AMG-548 has shown to be efficacious in acute and chronic models of arthritis.

Name: AMG 548
CAS#: 864249-60-5
Chemical Formula: C29H27N5O
Exact Mass: 461.22156
Molecular Weight: 461.56
Elemental Analysis: C, 75.46; H, 5.90; N, 15.17; O, 3.47

Synonym: AMG 548; AMG-548; AMG548; UNII-PGR0H531I4;

IUPAC/Chemical Name: 4(3H)-Pyrimidinone, 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-

InChi Key: RQVKVJIRFKVPBF-VWLOTQADSA-N

InChi Code: InChI=1S/C29H27N5O/c1-34-28(35)26(24-12-11-21-9-5-6-10-23(21)18-24)27(22-13-15-31-16-14-22)33-29(34)32-19-25(30)17-20-7-3-2-4-8-20/h2-16,18,25H,17,19,30H2,1H3,(H,32,33)/t25-/m0/s1

SMILES Code: Cn1c(=O)c(c(nc1NC[C@H](Cc2ccccc2)N)c3ccncc3)c4ccc5ccccc5c4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001