AMG-548
AMG-548 用途与合成方法
|
p38α 0.5 nM (Ki) |
p38β 3.6 nM (Ki) |
p38δ 2600 nM (Ki) |
p38γ 4100 nM (Ki) |
dog p38α 5.0 nM (Ki) |
JNK1 11480 nM (Ki) |
JNK2 39 nM (Ki) |
JNK3 61 nM (Ki) |
CK1
|
AMG-548 shows >1000 fold selective against p38γ (K
i
=2600 nM) and p38δ (k
i
=4100 nM). AMG-548 has an modest selectivity against JNK2 (k
i
=39 nM) and JNK3 (k
i
=61 nM). AMG-548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFa (IC
50
=3 nM) and IL1b (IC
50
=7 nM) as well as TNFa induced IL-8 (IC
50
=0.7 nM) and IL-1b induced IL-6 (IC50
50
=1.3 nM) in human whole blood.
AMG-548 (10 μM) inhibits the hDvl2 shift.
AMG-548 has rat F of 62% and dog F of 47%. The t 1/2 is 4.6 hours in rats and 7.3 hours in dogs.
AMG-548 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-108642 | AMG-548 | 864249-60-5 | 1 mg | 900 |
| 2026-06-05 | HY-108642 | AMG-548 | 864249-60-5 | 5 mg | 2700 |
