2-氯-5-硝基苯甲腈； GW 9662

中文名称

2-氯-5-硝基苯甲腈； GW 9662

英文名字

2-chloro-5-nitrobenzanilide； GW 9662

供应商

开曼生物

产品货号

70785-1

产品报价

￥138.6/1mg

产品说明书

点击查看

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料

The peroxisome proliferator-activated receptor γ （PPARγ） is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone （BRL 49653） is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists， including 15-deoxy-Δ12，14-prostaglandin J2 and azelaoyl PAF， which are naturally derived. However， only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 uM. It is therefore a much more potent antagonist than BADGE， which is another reported PPARγ antagonist.

产品描述

The peroxisome proliferator-activated receptor γ （PPARγ） is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPAR.gamma. agonists with antidiabetic actions in vivo. Rosiglitazone （BRL 49653） is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPAR.gamma. agonists， including 15-deoxy-.DELTA.12，14-prostaglandin J2 and azelaoyl PAF， which are naturally derived. However， only a few antagonists have been reported. GW 9662 blocks the PPAR.gamma.-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 uM. It is therefore a much more potent antagonist than BADGE， which is another reported PPAR.gamma. antagonist.

保存建议

建议您在收到开曼生物品牌的GW 9662 （1 mg）产品后置于-20度保存，产品有效期为730天.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的开曼生物产品以及客户订制化服务.