武汉艾必赛生物有限公司推荐Anti-Mouse Norovirus Capsid protein Recombinant Antibody (A6.2) ,精品抗体

链接：https://www.abinscience.cn/product/68/18453.html

名称：Anti-Mouse Norovirus Capsid protein Recombinant Antibody (A6.2)

Accession号：Q80J94

货号：VK566013

种属：Murine Norovirus 1

宿主：Mouse

同种型：IgG2a, kappa

克隆类型：Monoclonal

靶标：Capsid protein, ORF2

状态：Liquid

纯度：>90% as determined by SDS-PAGE.

应用：ELISA, Neutralization

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

产品介绍：Anti-Mouse Norovirus Capsid protein Recombinant Antibody (A6.2) (VK566013)是艾必赛生物（abinScience）推出的一款小鼠源单克隆抗体，专门用于检测小鼠诺如病毒（Murine Norovirus, MNV）的衣壳蛋白（Capsid protein）。该抗体通过Protein A/G纯化，适用于ELISA和中和实验（Neutralization）。其宿主为小鼠，同种型为IgG2a, kappa，克隆号为A6.2，靶向病毒衣壳蛋白VP1（由ORF2编码）。

小鼠诺如病毒属于杯状病毒科诺如病毒属，是一种单链正义RNA病毒。它于2003年由Karst等人首次从STAT1和RAG2双基因缺陷的免疫缺陷小鼠中分离发现。该病毒主要通过粪口途径传播，也可能通过唾液传播，是实验小鼠群中已知最普遍的偶发性病原体。在免疫缺陷小鼠中，MNV感染可引起脑炎、脑膜炎、肝炎、肠炎和肺炎等多种疾病，甚至导致死亡；而在免疫健全小鼠中，感染通常呈亚临床状态，但可长期排毒，成为持续传染源。其衣壳蛋白VP1（约58 kDa）能自我组装形成直径约38 nm的二十面体衣壳，负责介导病毒与宿主细胞受体CD300LF的结合，是病毒入侵的关键蛋白。由于人类诺如病毒难以在体外细胞中培养，MNV因其可在RAW264.7等细胞系中增殖，成为研究人类诺如病毒生物学、致病机制及抗病毒药物筛选的重要模型系统。因此，针对MNV衣壳蛋白的A6.2单克隆抗体不仅是研究该病毒入侵机制、宿主免疫应答的重要工具，也为相关诊断试剂、疫苗及抗病毒药物的研发提供了关键试剂支持。

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邮箱：info@abinscience.com

参考文献：

Human norovirus disturbs intestinal motility and transit time through its capsid proteins. PMID: 39602402
GII.6 norovirus major capsid protein VP1 derived from distinct clusters induce cross-blocking effects. PMID: 38857640
Functional diversity in GII.4 norovirus entry: HBGA binding and capsid clustering dynamics. PMID: 41032521
Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens. PMID: 27421712
Norovirus assembly and stability. PMID: 29857940
Characteristics of Norovirus capsid protein-specific CD8(+) T-Cell responses in previously infected individuals. PMID: 38803081
Norovirus Attachment and Entry. PMID: 31151248
Broadly neutralizing antibodies targeting pandemic GII.4 variants or seven GII genotypes of human norovirus. PMID: 40043137
Generation of Recombinant Rotaviruses Expressing Human Norovirus Capsid Proteins. PMID: 36314817
Linear epitopes on the capsid protein of norovirus commonly elicit high antibody response among past-infected individuals. PMID: 37280660
Dynamics in the murine norovirus capsid revealed by high-resolution cryo-EM. PMID: 32231352
Antigenic and glycan-binding characteristics of norovirus GII.20 capsid protein VP1. PMID: 40753875
Highly variable antigenic site located at the apex of GII.4 norovirus capsid protein induces cross-reactive blocking antibodies in a variant-specific manner. PMID: 40444947
Conformational Control of Fast Asparagine Deamidation in a Norovirus Capsid Protein. PMID: 36808948
Structural Basis for Human Norovirus Capsid Binding to Bile Acids. PMID: 30355683
Detection of Murine Norovirus on Fresh Produce Through a CRISPR/Cas13a RNase-Based Capsid Integrity Assay. PMID: 40544217
Out-of-sync evolutionary patterns and mutual interplay of major and minor capsid proteins in norovirus GII.2. PMID: 39331030
N-terminal insertion peptides produce varied effects over the cleavage and assembly of norovirus major capsid protein VP1. PMID: 41354798
Evidence of recombination in the norovirus capsid gene. PMID: 15795283
Epochal coevolution of minor capsid protein in norovirus GII.4 variants with major capsid protein based on their interactions over the last five decades. PMID: 35817094
Recombinant norovirus capsid protein VP1 (GII.4) expressed in H5 insect cells exhibits post-translational modifications with potential impact on lectin activity and vaccine design. PMID: 35312780
Mass Spectrometry-Based System for Identifying and Typing Norovirus Major Capsid Protein VP1. PMID: 34835138
Manipulation of immunodominant variable epitopes of norovirus capsid protein elicited cross-blocking antibodies to different GII.4 variants despite the low potency of the polyclonal sera. PMID: 40444946
Nanobodies targeting norovirus capsid reveal functional epitopes and potential mechanisms of neutralization. PMID: 29095961
Molecular evolution of the capsid gene in human norovirus genogroup II. PMID: 27384324
Murine norovirus allosteric escape mutants mimic gut activation. PMID: 40353669
GII.4 Human Norovirus: Surveying the Antigenic Landscape. PMID: 30791623
Fucose-Functionalized Precision Glycomacromolecules Targeting Human Norovirus Capsid Protein. PMID: 30071731
Biological and immunological characterization of major capsid protein VP1 from distinct GII.2 norovirus clusters. PMID: 39251865
Molecular Evolution of the Capsid Gene in Norovirus Genogroup I. PMID: 26338545
Norovirus capsid proteins self-assemble through biphasic kinetics via long-lived stave-like intermediates. PMID: 23822934
GII.17 norovirus re-emerged in the 2020s as a result of dynamic and adaptive evolutionary processes. PMID: 41285779
Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatment. PMID: 39396425
Norovirus vaccines under development. PMID: 28668568
A post-translational modification of human Norovirus capsid protein attenuates glycan binding. PMID: 30899001
A broadly protective human antibody for GI genogroup noroviruses. PMID: 40211068
Collision induced unfolding and molecular dynamics simulations of norovirus capsid dimers reveal strain-specific stability profiles. PMID: 38628116
Structural Studies on the Shapeshifting Murine Norovirus. PMID: 34834968
E. coli-expressed recombinant norovirus capsid proteins maintain authentic antigenicity and receptor binding capability. PMID: 15484274
The Dynamic Capsid Structures of the Noroviruses. PMID: 30857192
Genotype-Specific Neutralization of Norovirus Is Mediated by Antibodies Against the Protruding Domain of the Major Capsid Protein. PMID: 32179892
Norovirus GII.P16/GII.2-Associated Gastroenteritis, China, 2016. PMID: 28430563
Molecular Evolution and Epidemiology of Norovirus GII.4 Viruses in the United States. PMID: 40036172

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武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。

依托严格的产品研发体系和国际化的质量管理标准，武汉艾必赛与 AtaGenix、ProteoGenix 等知名品牌保持长期战略合作，现已构建起涵盖抗体、重组蛋白、工具酶、试剂盒、实验耗材在内的多品类供应体系，面向区域内科研机构、高校实验室与生物医药企业，提供稳定、高效、可信赖的产品与服务。

核心业务覆盖：
✅ 抗体产品（单抗、多抗、重组抗体等）
✅ 蛋白与多肽试剂（标签蛋白、功能蛋白等）
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武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。