长沙上禾生物staherb丁香提取物 Cloves Extract 主要活性成分中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

中文主要活性成分简介｜Key Active Constituents (CN)

产品：丁香提取物 Cloves Extract（桃金娘科 Myrtaceae 丁香 Syzygium aromaticum (L.) Merr. et Perry 干燥花蕾；俗名公丁香）

供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®，2010 年成立于长沙麓谷，环创企业广场 B8 202 室）

活性架构：丁香是"挥发油主导型"香料药，干花蕾含挥发油 15%–20%，其中 丁香酚 Eugenol 占 60%–90%（Staherb 标准提取物锁定 80%–90% 为金标准）；非挥发部分含鞣质 10%–13%、黄酮（槲皮素/山奈酚）、三萜（齐墩果酸/熊果酸）、β-谷甾醇。所有现代药理（抗菌/镇痛/抗炎/抗氧化/驱虫）可 90%+ 回溯到丁香酚单一分子，乙酰丁香酚与 β-石竹烯为"香气协同+部分药理补位"伴生体，不单独标化为等效主轴。

核心活性成分清单（Staherb 标定层级）

1. 丁香酚 Eugenol（绝对主轴）

• CAS 97-53-0；分子式 C₁₀H₁₂O₂；MW 164.20；化学名 4-烯丙基-2-甲氧基苯酚（2-methoxy-4-(prop-2-en-1-yl)phenol）；结构=邻甲氧基苯酚+烯丙基；外观无色至淡黄色油状液体（单体）/ 棕褐粉（提取物）；不溶于水、易溶于乙醇/乙醚/氯仿/丙二醇/油类、对热稳（100℃ 内不变）、遇金属离子变色沉淀、空气久置氧化变深；HPLC 定值波长 280 nm，GC 内标法同步复核；Staherb 供应 Eugenol 50% / 80% / 90% / 98% HPLC + 医药级 ≥99% 单体。

2. 乙酰丁香酚 Acetyleugenol（伴生香气体）

• CAS 93-28-7；C₁₂H₁₄O₃；MW 206.24；丁香酚酚羟基乙酰化衍生物；挥发油中占 2%–15%；保香、弱抗菌、调性温润；高标提取物 GC-MS 指纹监控，不单独标化含量。

3. β-石竹烯 β-Caryophyllene（伴生萜烯）

• 双环倍半萜烯；挥发油 5%–12%；CB2 大麻素受体弱激动、抗炎背景；与丁香酚协同口腔/皮肤舒缓；GC-MS 指纹项。

4. 非挥发伴行（背景级）：鞣质（没食子酸衍生）/槲皮素/山奈酚/齐墩果酸/熊果酸/β-谷甾醇——比例粉 4:1/10:1 TLC 背景，标准提取物不单列。

为什么"主要活性成分"以丁香酚为唯一金标准

丁香酚是酚类结构（邻甲氧基+烯丙基），其酚羟基清 ROS、烯丙基调 TRPV1/钙离子、甲氧基助脂溶透膜三位一体，决定了丁香"宽谱抗菌（G⁺/G⁻/真菌/口腔链球菌 MIC 3.125–6.25 mg/mL）+ 局部镇痛（TRPV1 调控背景）+ 抗炎 COX/NO 下调 + 抗氧化（与 VE 协同）+ 驱虫"的全部商业价值；乙酰丁香酚/β-石竹烯只做香气与边际补位。故 Staherb 原料页表述为"Eugenol as principal marker-active constituent; acetyleugenol/β-caryophyllene as companion volatile background"，严禁把"总挥发油"或"β-石竹烯"包装成等同活性。

⚠️ Staherb 合规边界：原料页统一表述"Eugenol (CAS 97-53-0) as principal active phenol of Syzygium aromaticum flower bud, active for antibacterial-background / oral-care-background / analgesic-TRPV1-background / antioxidant-background / food-flavoring-background"；不跨境宣称治疗牙痛急性发作/幽门螺杆菌阳性溃疡/龋齿/关节炎（属药品/医疗器械范畴）；原生 Eugenol 不溶于水、空气氧化变深、遇 Fe³⁺/Al³⁺ 变色、高浓度口腔黏膜刺激（麻木/灼伤背景），单体避光充氮 2–8℃ 存，标准提取物 2–8℃ 防潮；口腔产品控酚浓度（通常 <5% 游离 Eugenol）、外用乳膏 <10% 背景、孕妇高剂量内服问医、凝血障碍/术前 1 周问医（酚类影响血小板）。

English Key Active Constituents｜EN

Product: Clove Extract / Cloves Extract (Dried flower buds of Myrtaceae Syzygium aromaticum (L.) Merr. et Perry; common name Clove / Clove bud)

Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®)

Activity architecture: Clove is a volatile-oil-dominant spice-herb, dry bud contains 15%–20% essential oil, where Eugenol occupies 60%–90% (Staherb std extract locks 80%–90% as gold standard); non-volatile portion carries tannin 10%–13%, flavonoids (quercetin/kaempferol), triterpenes (oleanolic/ursolic acid), β-sitosterol. All modern pharmacology (antibacterial/analgesic/anti-inflammatory/antioxidant/insect-repellent) traces 90%+ to Eugenol alone; acetyleugenol & β-caryophyllene are "aroma-synergy + marginal pharmacological backup" companions, not individually standardized as equivalent spine.

Core active constituent list (Staherb tiering)

1. Eugenol (absolute spine)

• CAS 97-53-0; C₁₀H₁₂O₂; MW 164.20; 4-allyl-2-methoxyphenol (2-methoxy-4-prop-2-enylphenol); structure = ortho-methoxyphenol + allyl; appearance colorless-to-pale-yellow oily liquid (monomer) / brown powder (extract); water-insoluble, freely EtOH/Et₂O/CHCl₃/PG/oils, heat-stable (≤100℃), discolors with metal ions, oxidizes dark on air; HPLC assay 280 nm, GC internal-standard cross-check; Staherb supplies Eugenol 50%/80%/90%/98% HPLC + pharma-grade ≥99% monomer.

2. Acetyleugenol (companion aroma body)

• CAS 93-28-7; C₁₂H₁₄O₃; MW 206.24; acetylated phenolic OH derivative of eugenol; volatile oil 2%–15%; flavor-retention, weak antimicrobial, softens warmth; GC-MS fingerprint monitor in high-std extract, not separately standardized.

3. β-Caryophyllene (companion terpene)

• Bicyclic sesquiterpene; volatile oil 5%–12%; weak CB2 cannabinoid agonism, anti-inflammatory background; synergizes eugenol in oral/skin soothing; GC-MS fingerprint item.

4. Non-volatile companions (background): tannins (gallic-acid derived) / quercetin / kaempferol / oleanolic acid / ursolic acid / β-sitosterol — ratio powder 4:1/10:1 TLC background, not itemized in std extract.

Why "key active" centers on Eugenol alone

Eugenol is a phenol (ortho-methoxy + allyl): phenolic OH scavenges ROS, allyl tunes TRPV1/Ca²⁺, methoxy aids lipid-soluble membrane transit — trinity deciding clove's "broad-spectrum antimicrobial (G⁺/G⁻/fungi/S. mutans MIC 3.125–6.25 mg/mL) + local analgesia (TRPV1-mod background) + anti-inflammatory COX/NO down + antioxidant (synergistic with VE) + insect-repellent" commercial value; acetyleugenol/β-caryophyllene only do aroma & marginal backup. Hence Staherb labels "Eugenol as principal marker-active constituent; acetyleugenol/β-caryophyllene as companion volatile background", forbid packaging "total volatile oil" or "β-caryophyllene" as equivalent active.

Supplier note: Staherb labels Eugenol as "Eugenol (CAS 97-53-0) as principal active phenol of Syzygium aromaticum flower bud, active for antibacterial-background / oral-care-background / analgesic-TRPV1-background / antioxidant-background / food-flavoring-background" — no cross-border "treats acute toothache/H. pylori ulcer/dental caries/arthritis" claim (drug/device scope); native Eugenol water-insoluble, air-oxidizes dark, discolors with Fe³⁺/Al³⁺, high-conc mucosal irritancy (numb/burn background), monomer dark N₂ 2–8℃, std extract 2–8℃ dry; oral-care cap free eugenol (<5%), topical cream <10% background, pregnancy high-dose oral consult, coagulation-disorder/pre-1wk-surgery consult (phenol affects platelets).

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）