长沙上禾生物staherb丁香提取物 Cloves Extract 核心功效与药理作用中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

## 中文简介｜Core Efficacy & Pharmacological Actions (CN)

产品：丁香提取物 Cloves Extract（桃金娘科丁香 *Syzygium aromaticum* 干燥花蕾；丁香酚 Eugenol CAS 97-53-0 唯一标志酚）

供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®）

作用化学基础：丁香酚是4-烯丙基-2-甲氧基苯酚（邻甲氧基苯酚+烯丙基），其药理三位一体——酚羟基氢供体清 ROS、烯丙基调 TRPV1/TRPA1 与 Ca²⁺ 内流、甲氧基助脂溶透膜入微生物膜/神经末梢。它不是单一通路分子，而是"膜破坏抗菌+酚抗氧+TRP/离子通道镇痛+NF-κB 抗炎"四轴嵌合；乙酰丁香酚/β-石竹烯仅香气与边际协同。

作用特点：所有现代商业价值（口腔镇痛、广谱抗菌、天然防腐、抗氧化、辛香调味）可 90%+ 回溯到丁香酚单一分子；口服胃肠刺激背景、高浓度黏膜麻木灼伤背景、酚类影响血小板聚集背景。

### 核心功效（Core Efficacy）

- 广谱抗菌/抗真菌/抗生物膜（最硬主轴）：丁香酚疏水酚分区入微生物膜→通透性↑、质子动力势消散、ATPase 抑、胞内 ROS 爆发、DNA 损；对 G⁺（金葡/表葡/链球菌）、G⁻（大肠/绿脓/沙门/李斯特）、幽门螺杆菌、白色念珠菌/皮肤癣菌 MIC 通常 0.1–1.0 mg/mL（变形链球菌 0.08%–0.16% v/v、牙龈卟啉单胞菌 0.32%–0.64% ）；破生物膜、增敏耐药菌；食品/口腔/日化天然防腐底色。

- 局部镇痛与表面麻醉（牙科锚点）：调 TRPV1/TRPA1 受体通道+抑电压门控 Na⁺/Ca²⁺ 通道+阻神经复合动作电位+抑 PGE₂，外周痛觉脱敏，数分钟起效，强度近弱利多卡因/苯佐卡因（Alqareer 2006 丁香凝胶 vs 20% 苯佐卡因非劣 ）；牙科 ZOE（氧化锌丁香酚）暂封、牙髓炎安抚、拔牙后干槽症敷料背景。

- 抗炎与抗氧化双向：抑 NF-κB p65 核转位、COX-2、5-LOX、MAPK，降 TNF-α/IL-1β/IL-6/PGE₂/LTB₄；酚羟基清 DPPH/ABTS/超氧/羟自由基、止脂质过氧化、升 SOD/GSH-Px；USDA ORAC 314,446 µmol TE/100g（香料最高 ）。牙周炎牙龈炎症临观降 30%–40% 背景。

- 口腔健康主轴：抑变形链球菌产胞外葡聚糖→菌斑↓、龋风险↓；龈炎/牙周炎/口腔溃疡/义齿性口炎背景；牙膏 1%–3% 丁香酚当量、漱口水 0.5%–2% 常规窗。

• 消化与胃肠保护（传统主轴）：刺激唾液/胃液/胆汁、促胃肠蠕动但高剂量抑肠痉挛（抗乙酰胆碱/组胺背景）；5% 丁香酚乳增胃粘液不增酸度→抗实验性溃疡；体外抑幽门螺杆菌（非临床根除方案）。

- 驱虫与食品防腐：对螨/虱/蚤/蚊/肠道寄生虫驱避杀灭；赤道菜系重丁香作天然腌渍防腐背景。

• 科研级延展：抗血小板聚集（影响 TXA₂ 背景）、轻度降压、替抗饲料、抗肿瘤（线粒体凋亡/NF-κB 下调）细胞背景——非 Staherb 出口原料宣称项。

### 药理作用机制（Pharmacological Mechanism）

丁香酚药理来自"酚羟基氢供体抗氧化相 + 脂溶分区破膜抗菌相 + TRPV1/TRPA1 调控+Na⁺/Ca²⁺ 通道阻断镇痛相 + NF-κB/COX-2/5-LOX 抗炎相 + 胃粘液促泌抗溃疡相 + 驱虫膜毒相"六维嵌合：

1. 抗氧化相：酚-OH 捐 H 终止脂质过氧化链，清 DPPH/ABTS/·OH/O₂⁻。

2. 抗菌相：烯丙基+酚羟基入膜，通透性↑、ΔpH 消散、ATPase 抑、ROS 爆、内容物漏。

3. 镇痛相：TRPV1/TRPA1 初激动后脱敏 + VGSC/VGCC 阻断 + PGE₂↓。

4. 抗炎相：IKK/IκΒα/NF-κB p65 阻、COX-2/PGE₂↓、TNF-α/IL-1β/IL-6↓。

5. 胃肠相：胆碱能介导促胃液（阿托品可阻）+ 丁香酚增粘液不增酸 + 高剂量解痉。

6. 驱虫相：膜去极化、神经肌肉阻滞、线粒体毒。

> ⚠️ Staherb 合规边界：原料页统一表述"Eugenol (CAS 97-53-0) as principal active phenol of *Syzygium aromaticum* bud, active for antibacterial-background / oral-care-background / analgesic-TRPV1-background / anti-inflammatory-background / antioxidant-background / natural-preservative-background"；不跨境宣称治疗牙痛急性发作/幽门螺杆菌阳性溃疡/龋齿/牙周炎/关节炎（属牙科药品/医疗器械/处方范畴）；口腔产品控游离丁香酚 <5%、外用乳膏 <10% 背景；原生 Eugenol 不溶于水、空气氧化变深、遇 Fe³⁺/Al³⁺ 变色、高浓度黏膜麻木灼伤，单体避光充氮 2–8℃，标准提取物 2–8℃ 充氮防潮；孕妇高剂量内服问医、凝血障碍/术前 1 周问医（酚类影响血小板）、2 岁以下儿童口腔高浓禁用、牙科专业人士接触性皮炎 2%–5% 背景。

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## English Profile｜Core Efficacy & Pharmacological Actions (EN)

Product: Clove Extract / Cloves Extract (Dried flower buds of Myrtaceae *Syzygium aromaticum* (L.) Merr. et Perry; Eugenol CAS 97-53-0 sole marker phenol)

Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®)

Chemical basis: Eugenol = 4-allyl-2-methoxyphenol (ortho-methoxyphenol + allyl); pharmacology trinity — phenolic OH hydrogen-donor quenches ROS, allyl tunes TRPV1/TRPA1 & Ca²⁺ influx, methoxy aids lipid-soluble membrane transit; not single-pathway but "membrane-disrupt antimicrobial + phenolic antioxidant + TRP/ion-channel analgesic + NF-κB anti-inflammatory" four-axis embed; acetyleugenol/β-caryophyllene only aroma-margin synergy.

Action character: all modern commercial value (oral analgesia, broad-spectrum antimicrobial, natural preservative, antioxidant, pungent flavor) traces 90%+ to Eugenol alone; GI irritancy background, high-conc mucosal numb/burn background, phenol-affects-platelet background.

### Core Efficacy

• Broad-spectrum antimicrobial / antifungal / anti-biofilm (hardest spine): eugenol lipophilic phenol partitions into microbial membrane → permeability↑, proton-motive-force dissipate, ATPase inhibit, intracellular ROS burst, DNA damage; vs G⁺ (S. aureus / S. mutans), G⁻ (E. coli / P. aeruginosa / Salmonella / Listeria), H. pylori, C. albicans / dermatophytes MIC usually 0.1–1.0 mg/mL (S. mutans 0.08%–0.16% v/v, P. gingivalis 0.32%–0.64% ); disperses biofilm, sensitizes resistant strains; food/oral/cosmetic natural-preservative base.

• Topical analgesia & surface anesthesia (dental anchor): modulates TRPV1/TRPA1 + inhibits voltage-gated Na⁺/Ca²⁺ channels + blocks compound action potential + suppresses PGE₂, peripheral nociceptor desensitization within minutes, strength near mild lidocaine/benzocaine (Alqareer 2006 clove-gel non-inferior to 20% benzocaine ); ZOE temporary filling, pulpitis palliative, dry-socket dressing background.

• Anti-inflammatory & antioxidant bidirectional: inhibits NF-κB p65 nuclear transit, COX-2, 5-LOX, MAPK, lowers TNF-α/IL-1β/IL-6/PGE₂/LTB₄; phenolic OH scavenges DPPH/ABTS/·OH/O₂⁻, stops lipid peroxidation, ups SOD/GSH-Px; USDA ORAC 314,446 µmol TE/100g (highest of all spices ). Periodontitis gingival-inflammation clinical drop 30%–40% background.

• Oral-health spine: inhibits S. mutans extracellular glucan → plaque↓, caries-risk↓; gingivitis/periodontitis/aphthous/oral-candidiasis background; toothpaste 1%–3% eugenol-equivalent, mouthwash 0.5%–2% routine window.

• Digestive & gastro-protective (traditional spine): stimulates saliva/gastric/bile, promotes motility but high-dose antispasmodic (anti-ACh/Histamine background); 5% eugenol emulsion increases gastric mucus without acidity rise → anti-experimental-ulcer; in-vitro H. pylori inhibit (not clinical eradication regimen).

• Insect-repellent & food preservative: acaricide/pediculicide/mosquito/intestinal-parasite repel-kill; equatorial cuisines heavy-clove as natural pickling preservative background.

• Research-extended: anti-platelet (TXA₂ background), mild hypotension, antibiotic-replace feed, antitumor (mitochondrial apoptosis/NF-κB down) cell background — not Staherb export claim items.

### Pharmacological Mechanism

Eugenol from "phenolic-OH H-donor antioxidant phase + lipophilic partition membrane-disrupt antimicrobial phase + TRPV1/TRPA1 tune + Na⁺/Ca²⁺ channel block analgesic phase + NF-κB/COX-2/5-LOX anti-inflammatory phase + gastric-mucus secretagogue anti-ulcer phase + insect membrane-toxic phase" six-dimensional embed:

1. Antioxidant phase: phenolic-OH donates H, terminates lipid-peroxidation chain, clears DPPH/ABTS/·OH/O₂⁻.

2. Antimicrobial phase: allyl+phenol into membrane, permeability↑, ΔpH dissipate, ATPase inhibit, ROS burst, content leak.

3. Analgesic phase: TRPV1/TRPA1 initial activate then desensitize + VGSC/VGCC block + PGE₂↓.

4. Anti-inflammatory phase: IKK/IκΒα/NF-κB p65 block, COX-2/PGE₂↓, TNF-α/IL-1β/IL-6↓.

5. GI phase: cholinergic-mediated gastric juice ↑ (atropine-blockable) + eugenol mucus ↑ not acid ↑ + high-dose spasmolytic.

6. Insect phase: membrane depolarize, neuromuscular block, mitochondrial toxic.

Supplier note: Staherb labels Eugenol as "Eugenol (CAS 97-53-0) as principal active phenol of *Syzygium aromaticum* bud, active for antibacterial-background / oral-care-background / analgesic-TRPV1-background / anti-inflammatory-background / antioxidant-background / natural-preservative-background" — no cross-border "treats acute toothache/H. pylori ulcer/dental caries/periodontitis/arthritis" claim (dental-drug/device/prescription scope); oral cap free eugenol <5%, topical cream <10% background; native Eugenol water-insoluble, air-oxidizes dark, discolors with Fe³⁺/Al³⁺, high-conc mucosal numb/burn, monomer dark N₂ 2–8℃, std extract N₂ 2–8℃ dry; pregnancy high-dose oral consult, coagulation-disorder/pre-1wk-surgery consult (phenol affects platelets), <2yr child high-conc oral prohibit, dental-professional contact-dermatitis 2%–5% background.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）