长沙上禾生物Staherb人参皂苷 Ginsenosides专业生产中英文简介

发布人：长沙上禾生物科技有限公司

发布日期:2026/8/8 14:41:01

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

中文专业生产简介｜Professional Manufacturing (CN)

产品：人参提取物 / 人参皂苷 Ginsenosides（五加科人参 Panax ginseng C. A. Mey. 干燥根及根茎；白参总皂苷线 / 红参稀有皂苷线 / 发酵转化线 / 单体线四轨）

生产商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®，2010 年成立于长沙麓谷，2022 年设全资子公司湖南丁塔尔生物）

生产基地：长沙高新开发区麓谷环创企业广场 B8 202 室——水/稀醇提-大孔树脂/正丁醇萃皂苷段-生物转化-减浓-喷雾或冻干标化分装与出口质控中心（非种植产地，原料见前轮「原料产地」）。

产能与硬件：6 套 8 吨级提取罐、自动减浓、大孔树脂柱组（AB-8/D101/HZ-801/HP-20）、正丁醇萃取釜、乳酸菌/曲霉 β-葡糖苷酶生物转化罐、0.45 μm 微滤+UF、150 型离心喷雾（出风 75–85℃ 秒干）+ 冻干机、制备 HPLC C18（切 Rg1/Rb1/Re/Rg3/Rh2/CK）、Waters HPLC-UV/DAD@203 nm + UV-Vis 香草醛硫酸 + 重金/农残/微生物前处理全套；植物提取物综合产能千吨级，行销欧美/日韩/澳新等 60+ 国。

体系认证：ISO 9001 / ISO 22000 / GMP-like 内部执行 / HALAL / KOSHER；COA 双轨——总皂苷报"UV-Vis 香草醛-浓硫酸 544 nm 以 Re 计（Total Ginsenosides XX% w/w by vanillin-H₂SO₄, Re as standard）"+ 三峰 Rg1+Re+Rb1 HPLC-UV@203 nm（ChP CRS），红参批加 Rg3(20S)/Rh2/CK 选报。

专业生产工艺路线（四轨）

▍白参总皂苷线（醇提主轴）

前处理（CCP1）：定点基地 5–6 年生园参生晒根/须根→除杂→切片或 10–20 目粉碎；入厂快检水分≤12%、Rg1+Re+Rb1≥0.40%–0.50% DW、农残 47 项零检、Pb≤1/Cd≤0.3/As≤1 ppm、SO₂ 合药典。
提取：60%–80% 乙醇-水热回流或逆流 80–90℃×2–3 次（红参可 95–100℃ 蒸 2–3 h 后再提促稀有皂苷游离），料液比 1:8–12；合并→板框/离心→澄清黄棕滤液（pH 自然 5.5–6.5，强酸强碱敏）。
大孔富集（主推）：滤液上 AB-8/D101/HZ-801 中弱极树脂，上样 1–2 BV/h、pH 6.0–7.0；去离子水洗至无色（除糖/氨基酸/蛋白）→50%–75% 乙醇洗脱皂苷段（文献 50% EtOH 解吸近 90% 为最优段）→减浓回收乙醇 ≤60℃。
正丁醇萃取（传统并行）：浓缩液调 pH 7.0→水饱和正丁醇等体积萃 2–3 次（皂苷转有机相、糖留水相）→正丁醇相 ≤70℃ 蒸除→少量 EtOH 溶→喷干（或加 β-CD≤5% 抗吸湿）。
干燥标化：喷雾 160–180/75–85℃ 秒干或冻干→总皂苷 5%/10%/20%/30%/50%/80% UV(以 Re 计)+Rg1+Re+Rb1 HPLC 分峰。

▍红参稀有皂苷线

白参提液或红参蒸制后提液→酸/酶/热转化（95–100℃ 蒸制脱糖异构，或乳酸菌/曲霉 β-葡糖苷酶切 Rb1→Rd→F2→CK）→大孔+制备 HPLC 切峰→得 Rg3 0.5%–3%（可定制 ≥20%）、Rh2 0.1%–1%、CK 0.2%–1% 红参/发酵标化粉。

▍单体线

80% 总皂苷→硅胶柱预分→制备 HPLC C18 乙腈-水 203 nm 切 Rg1/Rb1/Re/Rg3(20S)/Rh2/CK→EtOH-水/MeCN-水 0–4℃ 重结晶→≥98%–99% HPLC-UV@203 nm（单体 -20℃ 避光充氮，需少量 EtOH/β-CD 增溶）。

全程敏控：皂苷糖苷键对强酸/强碱敏、>80℃ 久提母核稳但糖苷易重排、强光促降解；提取液控 pH 5.5–6.5、减浓 ≤60℃（单体线 ≤50℃ N₂）、喷雾出风 ≤85℃ 秒干或冻干；粉末充氮铝箔 2–8℃（单体 -20℃）防潮 18–24 月。

专业生产供货矩阵

白参总皂苷（UV-Vis 以 Re 计）：5% / 10% / 20% / 30% / 50% / 80%，并行 HPLC Rg1+Re+Rb1 1.2%–30%
红参/黑参粉：总皂苷 + Rg3 0.5%–3% / Rh2 0.1%–1% / CK 0.2%–1%
发酵人参：CK≥40% 富集批、Rg3≥20% 批
高纯单体：Rg1/Rb1/Re/Rc/Rd/20(S)-Rg3/Rh2/CK ≥98%–99% HPLC-UV@203 nm
水提全谱粉（侧重多糖）：总皂苷 5%–10% + 多糖 10%–30%
改型：β-CD 包合抗吸湿、磷脂复合、微囊水溶

⚠️ Staherb 生产合规边界：长沙麓谷 B8 为四轨提取标化分装中心非种植产地；COA 必注"Total Ginsenosides by vanillin-H₂SO₄ as Re"与"Rg1+Re+Rb1 by HPLC-UV@203 nm with ChP CRS"双方法；附 "No Notoginsenoside R1 / No Pseudoginsenoside F11" 鉴别人参/三七/西洋参；不宣称治疗慢性疲劳综合征/免疫缺损/阿尔茨海默/高血压/糖尿病/肿瘤，稀有皂苷 Rg3/Rh2 数据细胞/动物/放化疗辅助背景；所有出口批附 "food/dietary-ingredient & R&D intermediate, not self-medication；UV 总皂苷必注'以 Re 计'、HPLC 分峰必附 CRS；单体 -20℃ 避光充氮（需少量 EtOH/β-CD 增溶）；含活血抗凝背景成分，术前 1–2 周停、华法林联用问医；WADA 未禁但赛事申报背景成分" 警示。

English Professional Manufacturing｜EN

Product: Ginseng Extract / Ginsenosides (Root & rhizome of Panax ginseng C. A. Mey.; white-total-sap / red-rare-sap / ferment-convert / monomer — four tracks)

Manufacturer: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®, founded 2010 in Changsha Lugu Hi-tech, with wholly-owned Hunan Tynadal Biotech Inc. since 2022)

Production base: Changsha Lugu Hi-tech, Huanchuang Enterprise Plaza B8-202 — water/dil-EtOH extract – macroporous / n-butanol sapogenin-segment – bio-conversion – conc – spray/freeze-dry standardize & export QC center (not plantation site; gardens see prior "Origin").

Capacity & hardware: 6×8-ton extract tanks, auto vac-conc, macroporous group (AB-8/D101/HZ-801/HP-20), n-butanol extractor, lactic/Aspergillus β-glucosidase convert tank, 0.45 μm MF+UF, 150-type centrifugal spray (outlet 75–85℃) + freeze-dryer, prep-HPLC C18 (cut Rg1/Rb1/Re/Rg3/Rh2/CK), Waters HPLC-UV/DAD@203 nm + UV-Vis vanillin-H₂SO₄ + heavy/pesticide/microbio prep; ~thousand-ton comprehensive capacity, 60+ countries.

System certs: ISO 9001 / ISO 22000 / GMP-like in-house / HALAL / KOSHER; COA dual-track — total sap "UV-Vis vanillin-H₂SO₄ 544 nm as Re (Total Ginsenosides XX% w/w by vanillin-H₂SO₄, Re as standard)" + three-peak Rg1+Re+Rb1 HPLC-UV@203 nm (ChP CRS), red batch adds Rg3(20S)/Rh2/CK optional.

Professional process route (four tracks)

▍White total-sap line (EtOH-extraction spine)

Pre-treatment (CCP1): registered 5–6 yr garden sun-dry root/fiber → decontaminate → slice or 10–20 mesh mill; inbound moisture≤12%, Rg1+Re+Rb1≥0.40%–0.50% DW, 47-pesticide zero, Pb≤1/Cd≤0.3/As≤1 ppm, SO₂ per ChP.
Extract: 60%–80% EtOH-water reflux or counter-current 80–90℃×2–3 (red ginseng pre-steam 95–100℃ 2–3 h to free rare sap), ratio 1:8–12; merge → plate-frame/centrifuge → clear yellow-brown filtrate (pH 5.5–6.5, acid/base-labile glycosidic bonds).
Macroporous enrich (primary): on AB-8/D101/HZ-801 mid-weak polar, 1–2 BV/h, pH 6.0–7.0; DI-water wash colorless (sugar/AA/protein out) → 50%–75% EtOH elute sapogenin segment (lit 50% EtOH desorb ~90% optimal) → conc recover EtOH ≤60℃.
n-Butanol extract (traditional parallel): conc adjust pH 7.0 → water-sat n-BuOH equal-vol extract 2–3× (sap to org, sugar in aq) → BuOH phase ≤70℃ strip → few EtOH dissolve → spray-dry (or +β-CD≤5% anti-hygroscopic).
Dry & standardize: spray 160–180/75–85℃ second-dry or FD → total 5%/10%/20%/30%/50%/80% UV(as Re) + Rg1+Re+Rb1 HPLC.

▍Red rare-sap line

White extract or red-steamed extract → acid/enzyme/heat convert (95–100℃ steam deglyco-isomerize, or lactic/Aspergillus β-glucosidase Rb1→Rd→F2→CK) → macroporous + prep-HPLC cut → Rg3 0.5%–3% (custom ≥20%), Rh2 0.1%–1%, CK 0.2%–1% red/ferment std powder.

▍Monomer line

80% total → silica pre-split → prep-HPLC C18 MeCN-water 203 nm cut Rg1/Rb1/Re/Rg3(20S)/Rh2/CK → EtOH-water/MeCN-water 0–4℃ recrystallize → ≥98%–99% HPLC-UV@203 nm (monomer -20℃ dark N₂, few EtOH/β-CD solubilize).

Sensitive control: saponin glycosidic bonds acid/base-labile, >80℃ long extract sapogenin stable but glycosidic rearrange, light degrade — extract pH 5.5–6.5, conc ≤60℃ (monomer ≤50℃ N₂), spray outlet ≤85℃ second-dry or FD; powder N₂ foil 2–8℃ (monomer -20℃) dry 18–24 mo.

Professional supply matrix

White total-sap (UV-Vis as Re): 5%/10%/20%/30%/50%/80%, parallel HPLC Rg1+Re+Rb1 1.2%–30%
Red/black ginseng: total + Rg3 0.5%–3% / Rh2 0.1%–1% / CK 0.2%–1%
Fermented ginseng: CK≥40% enriched, Rg3≥20% lot
High-pure monomer: Rg1/Rb1/Re/Rc/Rd/20(S)-Rg3/Rh2/CK ≥98%–99% HPLC-UV@203 nm
Water-ext whole-spectrum (polysac-lean): total 5%–10% + polysac 10%–30%
Modified: β-CD inclusion anti-hygroscopic, phospholipid complex, microencap water-disp

Supplier note: Staherb Changsha Lugu B8 = four-track extraction-standardization-repack center not plantation; COA must state "Total Ginsenosides by vanillin-H₂SO₄ as Re" and "Rg1+Re+Rb1 by HPLC-UV@203 nm with ChP CRS" dual-method; attach "No Notoginsenoside R1 / No Pseudoginsenoside F11" to exclude notoginseng/American-ginseng; label only "dammarane triterpene saponin matrix active for adaptogen-background / anti-fatigue / immune-background / neuro-background / cardio-background / antioxidant / pharma R&D reference" — no "treats chronic-fatigue/immunodeficiency/Alzheimer/HTN/diabetes/cancer" claim, rare Rg3/Rh2 data cell/animal/adjunct background only; every export lot carries "food/dietary-ingredient & R&D intermediate, not self-medication; UV total must state 'as Re', HPLC peaks with CRS; monomer -20℃ dark N₂ (few EtOH/β-CD); blood-activating/anticoagulant-background, stop 1–2 wk pre-surgery, consult physician on warfarin; WADA not banned but declare as background ingredient in sports" warning.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）