长沙上禾生物Staherb姜黄提取物Turmeric extract主要活性成分中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

中文主要活性成分简介｜Key Active Constituents (CN)

产品：姜黄提取物 Turmeric Extract / 姜黄素 Curcuminoids（姜科 Zingiberaceae 姜黄 Curcuma longa L. 干燥根茎）

供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®）

整体提取物无单一 CAS，以 姜黄素 Curcumin CAS 458-37-7 作首要 HPLC Marker、以 总姜黄素 Curcuminoids（Curcumin+DMC+BDMC 之和） 作标化总量标识；挥发油段以 姜黄酮 Turmerone / 芳姜黄酮 ar-Turmerone 作 GC-MS 伴行 Marker。

规格—活性对应（Staherb 标化）：

• 总姜黄素（HPLC，三者之和）：5% / 10% / 30% / 50% / 65% / 95%（95% 批按 USP 比例：Curcumin 70%–80%、DMC 15%–25%、BDMC 2.5%–6.5%）；

• 高纯单体：Curcumin ≥95% / 98% HPLC-UV@425 nm（橙黄至红棕结晶粉）；

• 全谱/比例粉：10:1 / 20:1 / 30:1，挥发油 ≥2%–10% GC、姜黄酮/芳姜黄酮定性定量选报；

• 改型：水溶性姜黄素（10%–20% HPLC，β-CD/磷脂/纳米乳）、四氢姜黄素（Tetrahydrocurcumin 36062-04-1 选供）。

姜黄不是"单分子植物"，而是"二芳基庚烷类姜黄素三联体（主轴）+ 姜黄酮倍半萜挥发油 + 少量多糖/甾醇"嵌合矩阵，主要活性成分分述如下：

1. 姜黄素 Curcumin（绝对主轴与 HPLC Marker）

• 1,7-双(4-羟基-3-甲氧基苯基)-1,6-庚二烯-3,5-二酮（二feruloyl methane），C₂₁H₂₀O₆ / MW 368.38，CAS 458-37-7，橙黄至红棕结晶；酮-烯醇互变异构（酸/中性酮式为主、碱性烯醇式红褐），pH 1–6 稳、不溶于水、溶于乙醇/丙酮/DMSO/油脂；占干姜黄 2%–5% DW、占姜黄素类 70%–77%。

• 是 NF-κB/MAPK/Nrf2/PI3K-Akt 多靶点抑制的经典多酚，也是食品级黄色素（E100 背景）。

2. 去甲氧基姜黄素 Demethoxycurcumin（DMC，伴行第二峰）

• 4-羟基-3-甲氧基与 4-羟基对称去一个 OMe，C₂₀H₁₈O₅ / MW 338.35，CAS 22608-11-3；占姜黄素类 15%–25%（USP 95% 批下限）。

• 部分研究示其 NLRP3/肠屏障/生物利用度略优于 Curcumin 本体（DMC 在 DSS 结肠炎模型抗炎伴行更强背景）。

3. 双去甲氧基姜黄素 Bisdemethoxycurcumin（BDMC，伴行第三峰）

• 两端均去 OMe 的对称二羟基二苯基庚二烯二酮，C₁₉H₁₆O₄ / MW 308.33，CAS 24939-16-8（文献亦见 33171-05-0 同物异录）；占姜黄素类 2.5%–6.5%（USP 95% 批下限）。

• 抗氧化/金属螯合背景，体外活性常介于 Curcumin 与 DMC 之间。

4. 挥发油段——姜黄酮类（Turmerones，伴行调性分子）

• 姜黄酮 Turmerone（C₁₅H₂₂O/MW218）、芳姜黄酮 ar-Turmerone（C₁₅H₂₂O/MW218）、姜烯 Zingiberene 等倍半萜；占根茎挥发油主体，赋予姜黄特有芳香与部分抗炎/促胆汁/神经背景，但不算"姜黄素类"总量。

• Staherb 全谱批随 GC-MS 报"Volatile oil ≥2%–10%，Turmerone/ar-Turmerone 定性定量"。

5. 伴生微量

• 四氢姜黄素 Tetrahydrocurcumin（36062-04-1，体内还原代谢物，更水溶）、二氢姜黄素、环姜黄素、姜黄多糖、豆甾醇/β-谷甾醇——与姜黄素类协同"抗炎-抗氧化"背景。

为什么它是"主要活性成分"表述难点

姜黄功效不是单分子负责——Curcumin 是首要 Marker 与多酚主轴，DMC/BDMC 伴行协同（三者之和才叫"总姜黄素"），Turmerone 管芳香与部分胆道/神经背景，多糖/甾醇补位。Staherb 原料页表述为"Curcumin as primary diarylheptanoid marker + DMC/BDMC as companion curcuminoids (sum = total curcuminoids) + turmerones as volatile companion"，并强制标注"总姜黄素 HPLC 必含三峰比例，不可只报 Curcumin 冒充 95% 姜黄素类"；单体 Curcumin≥98% 另线。

Staherb 产品中的活性表达形态

• 标化提取物：总姜黄素 5%–95% HPLC（95% 批三峰合 USP）、10:1–30:1 全谱粉（伴挥发油）；

• 高纯单体：Curcumin≥95%/98% HPLC-UV@425 nm 橙晶；

• 改型：水溶性姜黄素 10%–20%、磷脂复合（吸收 5–10×）、纳米姜黄素（生物利用度 20–30× 背景）、四氢姜黄素选供。

⚠️ Staherb 合规边界：原料页统一表述"diarylheptanoid curcuminoid matrix (Curcumin-led + DMC + BDMC) + turmerone volatile companion active for anti-inflammatory-background / antioxidant / metabolic-background / neuro-background / natural colorant / pharma R&D reference"；Curcumin 口服生物利用度极低（<1%–5%）、水溶差、碱性变红褐、Fe³⁺/Cu²⁺ 变色，不作"治疗类风湿关节炎/肿瘤/阿尔茨海默/脂肪肝"主治宣称；所有出口批附 "food/dietary-ingredient & R&D intermediate, not self-medication；充氮铝箔避光 2–8℃ 防潮（单体 -20℃）；配方避强碱（pH>7 变红褐）、避 Fe/Cu 离子、需磷脂/β-CD/胡椒碱/纳米乳增溶；抗凝药/胆石症/术前 1–2 周联用问医；长期高剂量 >3–8 g 原生姜黄粉/日 遵当地上限" 警示。

English Key Active Constituents｜EN

Product: Turmeric Extract / Curcuminoids (Rhizome of Curcuma longa L., Zingiberaceae)

Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®)

Whole extract no single CAS, flagged by Curcumin CAS 458-37-7 as primary HPLC marker, Total Curcuminoids (Curcumin + DMC + BDMC sum) as standardized total, Turmerone / ar-Turmerone as GC-MS volatile companion.

Spec↔active map (Staherb):

• Total Curcuminoids (HPLC 3-peak sum): 5%/10%/30%/50%/65%/95% (95% batch per USP: Curcumin 70%–80%, DMC 15%–25%, BDMC 2.5%–6.5%);

• High-pure monomer: Curcumin ≥95%/98% HPLC-UV@425 nm (orange-reddish-brown crystal);

• Full-spectrum/ratio: 10:1/20:1/30:1, volatile oil ≥2%–10% GC, turmerone/ar-turmerone optional quant;

• Modified: water-soluble curcumin 10%–20% (β-CD/phospholipid/nano-emulsion), tetrahydrocurcumin (36062-04-1) optional.

Turmeric is not a single-molecule herb but a "diarylheptanoid curcuminoid triplet (spine) + turmerone sesquiterpene volatile oil + minor polysaccharide/sterol" embed; key actives:

1. Curcumin — absolute spine & HPLC marker

• 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (diferuloylmethane), C₂₁H₂₀O₆ / MW 368.38, CAS 458-37-7, orange-reddish-brown crystal; keto-enol tautomer (keto dominant acid/neutral, enol red-brown alkaline), stable pH 1–6, water-insoluble, soluble EtOH/acetone/DMSO/oils; 2%–5% DW of dry rhizome, 70%–77% of curcuminoid fraction.

• Classic polyphenol inhibiting NF-κB/MAPK/Nrf2/PI3K-Akt multi-target; also food yellow color (E100 background).

2. Demethoxycurcumin (DMC) — companion 2nd peak

• One OMe removed symmetrically, C₂₀H₁₈O₅ / MW 338.35, CAS 22608-11-3; 15%–25% of curcuminoids (USP 95% floor).

• Some studies show NLRP3/gut-barrier/bioavailability slightly superior to Curcumin itself (DMC stronger companion in DSS-colitis background).

3. Bisdemethoxycurcumin (BDMC) — companion 3rd peak

• Both OMe removed symmetric dihydroxy-diarylheptadienedione, C₁₉H₁₆O₄ / MW 308.33, CAS 24939-16-8 (also recorded 33171-05-0); 2.5%–6.5% of curcuminoids (USP 95% floor).

• Antioxidant/metal-chelating background, in-vitro activity between Curcumin and DMC.

4. Volatile oil — turmerones (companion tone molecules)

• Turmerone (C₁₅H₂₂O/MW218), ar-Turmerone (C₁₅H₂₂O/MW218), zingiberene sesquiterpenes; main of rhizome volatile oil, give characteristic aroma + partial anti-inflammatory/cholagogue/neuro background, NOT counted in "curcuminoids total**.

• Staherb full-spectrum batch reports "Volatile oil ≥2%–10% GC, turmerone/ar-turmerone qual/quant".

5. Minor companions

• Tetrahydrocurcumin (36062-04-1, in-vivo reduced metabolite, more water-soluble), dihydrocurcumin, cyclo-curcumin, turmeric polysaccharide, stigmasterol/β-sitosterol — synergy with curcuminoids "anti-inflammatory-antioxidant" background.

Why "key active" is a matrix statement

Turmeric efficacy not one molecule — Curcumin is primary marker & polyphenol spine, DMC/BDMC companion-synergize (their sum = total curcuminoids), turmerones run aroma & partial biliary/neuro background, polysac/sterol fill. Staherb labels "Curcumin as primary diarylheptanoid marker + DMC/BDMC as companion curcuminoids (sum = total curcuminoids) + turmerones as volatile companion" and mandates "total curcuminoids HPLC must report 3-peak ratio, cannot report only Curcumin to fake 95% curcuminoids"; Curcumin≥98% monomer separate line.

Active form in Staherb portfolio

• Std extract: total curcuminoids 5%–95% HPLC (95% USP 3-peak), 10:1–30:1 full-spectrum (with volatile oil);

• High-pure: Curcumin≥95%/98% HPLC-UV@425 nm orange crystal;

• Modified: water-soluble 10%–20%, phospholipid complex (5–10× uptake), nano-curcumin (20–30× bioavailability background), tetrahydrocurcumin optional.

Supplier note: Staherb labels Turmeric Extract as "diarylheptanoid curcuminoid matrix (Curcumin-led + DMC + BDMC) + turmerone volatile companion active for anti-inflammatory-background / antioxidant / metabolic-background / neuro-background / natural colorant / pharma R&D reference" — Curcumin oral bioavailability very low (<1%–5%), water-poor, alkaline red-brown, Fe³⁺/Cu²⁺ discolor, no "treats RA/tumor/Alzheimer/NAFLD" indication; every export lot carries "food/dietary-ingredient & R&D intermediate, not self-medication; N₂ foil dark 2–8℃ dry (monomer -20℃); formula avoid strong alkali (pH>7 red-brown), avoid Fe/Cu ions, need phospholipid/β-CD/piperine/nano-emulsion solubilize; anticoagulant/gallstone/pre-1–2wk-surgery consult physician; long-term >3–8 g raw turmeric/day follow local cap" warning.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）