长沙上禾生物Staherb柚皮甙二氢查耳酮 Naringin dihydrochalcone专业生产中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

中文专业生产简介｜Professional Manufacturing (CN)

产品：柚皮甙二氢查耳酮 Naringin Dihydrochalcone（NDHC / Naringin DC，CAS 18916-17-1，C₂₇H₃₄O₁₄/MW 582.55）

生产商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®）

化学身份：非植物直接提取物，而是柑橘黄酮苷半合成衍生分子——以芸香科柑橘属果皮/幼果提得的柚皮苷 Naringin（CAS 10236-47-2，98% HPLC 级）为前体，经碱液开环→催化加氢→酸化析晶→重结晶三段改性制得。

厂区定位：长沙高新麓谷基地（环创企业广场 B8 202 室）为前体柚皮苷接收-碱开环/催化加氢-重结晶标化-微粉/预溶包定制分装与出口质控中心；前体柚皮苷来自川/赣/浙/桂/湘柑橘加工带定点备案基地（见前轮「原料产地」），长沙麓谷 B8 非种植产地、非直提车间。

CAS/分子：18916-17-1｜C₂₇H₃₄O₁₄｜582.55｜mp 131–132℃｜白色至类白结晶性粉末，微溶于水（热水/稀碱/乙醇助溶），pH 4–7 稳。

规格产出：90% / 95% / 98% / 99% HPLC-UV@282 nm（白晶，附 ¹H/¹³C-NMR+MS）；物理形态可选标准流动粉/微粉化速溶（D90≤10 μm）/预溶水溶液；前体 Naringin 98% HPLC 同线供应。

敏控红线：加氢段涉 H₂ 高压（0.5–3 MPa）+ Pd/C 贵金属催化剂，属受限工艺；终产品须控 Pd 残留 ≤5 ppm、EtOH 残留 ≤500 ppm、无 NaOH/KOH 碱残留（pH 5–7 析晶洗净）；NDHC 微吸水，游离碱态密封 2–8℃ 干燥避光 24 月。

专业生产工艺链（Staherb SOP 概要）

1. 前体准备（双轨）：

   
   

• 外采路线：定点基地柚/葡萄柚/枳实幼果皮渣 → 60%–80% 乙醇提 → AB-8 大孔富集 → 水/乙醇重结晶 → Naringin 98% HPLC 作投料（Staherb 双轨溯源）；

  
  

• 入厂拒收：Naringin 初含量 <3% DW、硫熏 SO₂>150 ppm、农残超 GB 2763、霉变皮。

  
  

2. 碱液开环（查尔酮中间体）：Naringin 投料溶于 4%–15% KOH 或 NaOH 水溶液（柚皮苷:碱质量比 ~3:1.5，终 pH~13），40–80℃ 搅溶 30–70 min，TLC/UV 监黄→查尔酮位移（C2=C3 开环），滤液除不溶物；可补 5%–50% 乙醇/甲醇助溶（文献 CN105801636A 参 ）。

   
   

3. 催化加氢（C2=C3 饱和）：开环液进高压釜，加 10% Pd/C（投料 1%–20% w/w 柚皮苷，主用 5%–10%） 或 Raney Ni，通 H₂ 0.5–3 MPa（主用 0.5–1.2 MPa）、20–60℃（主用 50℃）加氢 5–12 h（主用 6–8 h），至不吸氢；滤除 Pd/C（再生/危废合规处置），氢化液无双键（HPLC 单峰）。

   
   

4. 酸化析晶与重结晶（A 线）：氢化液 HCl/H₃PO₄ 调 pH 5–7，搅拌降温 <20℃ 析晶，离心得 NDHC 粗品；粗品以 15% 乙醇 6 倍量热溶 + 1%–4% 活性炭脱色 25 min → 冷却 4–20℃ 重结晶 2–3 次 → 60℃ 真空干燥（避光 N₂） 得 98%/99% HPLC 白晶；低标 90%/95% 可跳最后一次重结晶直接干法标化。

   
   

5. 物理成型（B 线，选做）：98%+ 晶体 → 气流微粉（D90≤10 μm 速溶）或预溶入热水/丙二醇得定制浓度水溶液（食品客户后段直添）；与赤藓糖醇/甜菊糖苷预混矫苦包（微胶囊化）。

   
   

6. 筛分与质控：80–100 目旋振筛 → 同标多批 V 混 → HPLC-UV@282 nm 外标报纯度% + 特征杂质 Naringin/开环查尔酮/柚皮素残留检 + 甜度比对（5% 蔗糖参比 300–500×）+ 亚阈掩苦模型（柚皮苷苦液）+ Pd≤5 ppm/重金属 Pb≤1 Cd≤0.3 As≤1/Hg≤0.1 + EtOH≤500 ppm + 微生物 TPC≤1000 cfu/g → 金属探测。

   
   

7. 分装与溯源：1/5/25 kg 内层棕铝箔+外纸板桶充氮；科研装 10 mg–1 g 棕玻瓶 2–8℃ 避光。双向链：NDHC 批号 ← Naringin 98% 批号 ← 柑橘皮渣/幼果基地批号。

   
   

质量与体系

• 车间：独立前体接收-碱开环釜-高压加氢釜（防爆）-析晶重结晶-微粉分装线，长沙麓谷 B8 控温控湿充氮避光，H₂ 区防爆隔离，Pd/C 危废合规处置。

  
  

• 认证：ISO 9001 / ISO 22000(HACCP) / GMP 类推（Staherb 公开资质）；HALAL、KOSHER、Non-GMO 声明。

  
  

• 仪器：HPLC-UV@282 nm、HPLC-ELSD（糖苷）、¹H/¹³C-NMR、LC-MS/MS（杂质）、ICP-MS（Pd/重金属）、GC（EtOH 残留）、粒度仪、甜度感官小组。

  
  

• 标准依据：企业标准 Q/STAHERB 001（对齐 JECFA 2208 / FEMA 4495 / GB 2760 柚皮苷二氢查耳酮）、HPLC 外标法。

  
  

⚠️ 具体碱浓度-加氢压力曲线-重结晶溶剂比-微粉粒径为 Staherb 专有 SOP，采购可索要典型工艺说明与 COA 样本；NDHC 是半合成柑橘衍生分子，所有出口批贴 "food/flavoring & R&D intermediate, not self-medication；semisynthetic from citrus naringin, not direct plant extract；poorly water-soluble use hot-water/EtOH, 2–8℃ dry dark；per GB 2760 / FEMA 4495 / JECFA 2208 ADI 0–5 mg/kg bw" 警示。

English Professional Manufacturing｜EN

Product: Naringin Dihydrochalcone (NDHC / Naringin DC, CAS 18916-17-1, C₂₇H₃₄O₁₄/MW 582.55)

Manufacturer: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®)

Chemical identity: Not a direct botanical extract but a semisynthetic derivative — precursor Naringin (CAS 10236-47-2, 98% HPLC grade) from Rutaceae citrus peel/immature fruit, converted via alkaline ring-open → catalytic hydrogenation → acid crystallization → recrystallization.

Site role: Changsha Lugu (Hi-tech, B8 Huanchuang 202) base = precursor naringin receive – alkaline ring-open/H₂-reduction – recrystallize standardize – micronize/pre-sol customize repack & export QC center; precursor naringin from Sichuan/Jiangxi/Zhejiang/Guangxi/Hunan citrus-processing registered bases (see prior "Origin" round), Changsha Lugu B8 not plantation site, not direct-extraction workshop.

CAS/Formula: 18916-17-1｜C₂₇H₃₄O₁₄｜582.55｜mp 131–132℃｜white to off-white crystals, poorly water-soluble (hot-water/dilute-alkali/EtOH aid), stable pH 4–7.

Output specs: 90% / 95% / 98% / 99% HPLC-UV@282 nm (white crystals, ¹H/¹³C-NMR+MS); physical form optional standard flow / micronized instant (D90≤10 μm) / pre-dissolved aq; precursor Naringin 98% HPLC same-line.

Sensitive redlines: hydrogenation involves H₂ high-pressure (0.5–3 MPa) + Pd/C noble-metal catalyst, restricted process; finished must control Pd≤5 ppm, EtOH≤500 ppm, no NaOH/KOH residue (pH 5–7 wash-crystallized); NDHC slightly hygroscopic, free-form sealed 2–8℃ dry dark 24 mo.

Dedicated Production Chain (Staherb SOP summary)

1. Precursor prep (dual-track): external route — registered-base pomelo/grapefruit/zhishi peel-dreg → 60%–80% EtOH extract → AB-8 enrich → H₂O/EtOH recrystallize → Naringin 98% HPLC feed (Staherb dual genealogy); reject Naringin initial <3% DW, SO₂>150 ppm, pesticide over GB 2763, mold.

   
   

2. Alkaline ring-open (chalcone intermediate): Naringin in 4%–15% KOH or NaOH aq (naringin:alkali ~3:1.5 w/w, final pH~13), 40–80℃ dissolve 30–70 min, TLC/UV monitor yellow→chalcone shift (C2=C3 open), filter insolubles; optional 5%–50% EtOH/MeOH cosolvent (ref CN105801636A ).

   
   

3. Catalytic hydrogenation (C2=C3 saturate): ring-open liquor to autoclave, add 10% Pd/C (1%–20% w/w naringin, mainly 5%–10%) or Raney Ni, H₂ 0.5–3 MPa (mainly 0.5–1.2 MPa), 20–60℃ (mainly 50℃), 5–12 h (mainly 6–8 h) till no H₂ uptake; filter Pd/C (regenerate/compliant hazardous waste), hydrogenate liquor single HPLC peak.

   
   

4. Acid crystallize & recrystallize (Line A): hydrogenate liquor HCl/H₃PO₄ to pH 5–7, stir cool <20℃ crystallize, centrifuge NDHC crude; crude in 15% EtOH 6× hot-dissolve + 1%–4% activated carbon 25 min → cool 4–20℃ recrystallize 2–3× → 60℃ vacuum dry (dark N₂) to 98%/99% HPLC white crystal; 90%/95% can skip last recrystallization direct dry-standardize.

   
   

5. Physical forming (Line B, optional): 98%+ crystal → jet micronize (D90≤10 μm instant) or pre-dissolve in hot-water/propylene glycol to custom conc (beverage post-stage); pre-blend with erythritol/stevia bitter-cut microcap.

   
   

6. Sieve & QC: 80–100 mesh vibratory → V-blend same-spec → HPLC-UV@282 nm purity% + char-impurity Naringin/chalcone/naringenin check + sweetness ratio (5% sucrose ref 300–500×) + sub-threshold bitter-mask model (naringin-bitter) + Pd≤5 ppm / Pb≤1 Cd≤0.3 As≤1 Hg≤0.1 + EtOH≤500 ppm + TPC≤1000 cfu/g → metal detect.

   
   

7. Pack & genealogy: 1/5/25 kg inner brown-foil + fiber drum N₂; R&D 10 mg–1 g amber 2–8℃ dark. Bidirectional: NDHC lot ← Naringin 98% lot ← citrus peel/immature-fruit base lot.

   
   

Quality System

• Workshop: independent precursor receive – alkaline ring-open kettle – high-pressure H₂ autoclave (explosion-proof) – crystallize-recrystallize – micronize repack line, Changsha Lugu B8 temp-RH N₂ dark controlled, H₂ zone isolated, Pd/C compliant disposal.

  
  

• Certs: ISO 9001 / ISO 22000(HACCP) / GMP-like (Staherb public); HALAL, KOSHER, Non-GMO declaration.

  
  

• Instruments: HPLC-UV@282 nm, HPLC-ELSD, ¹H/¹³C-NMR, LC-MS/MS (impurity), ICP-MS (Pd/heavy metal), GC (EtOH resid), particle sizer, sweetness sensory panel.

  
  

• Standards: Enterprise Q/STAHERB 001 (aligned JECFA 2208 / FEMA 4495 / GB 2760 naringin dihydrochalcone), HPLC external standard.

  
  

Supplier note: Exact alkali conc-H₂ pressure curve-recrystallization solvent ratio-micronize size are Staherb proprietary SOP — typical process sheet & COA sample on inquiry; NDHC is semisynthetic citrus-derived molecule, every export lot labels "food/flavoring & R&D intermediate, not self-medication; semisynthetic from citrus naringin, not direct plant extract; poorly water-soluble use hot-water/EtOH, 2–8℃ dry dark; per GB 2760 / FEMA 4495 / JECFA 2208 ADI 0–5 mg/kg bw" warning.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）