武汉艾必赛生物有限公司推荐Recombinant FMDV (SAT-1) VP1 Protein, N-His,精品蛋白

链接：https://www.abinscience.cn/product/78/54997.html

名称：Recombinant FMDV (SAT-1) VP1 Protein, N-His

Accession号：A0A7L4XQ62

货号：VK500132

种属：Foot-and-mouth disease virus SAT 1

表达系统：E. coli

状态：Lyophilized

纯度：>90% as determined by SDS-PAGE.

蛋白长度：Thr725-Gln943

应用：ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

预测分子量 26.64 kDa

用途范围：仅用于科研

储存： Use  a manual defrost freezer and avoid repeated freeze thaw cycles. Store  at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months  from the date of receipt.

产品介绍：近期，我国首次发生输入性南非1型（SAT1）口蹄疫疫情，该血清型为非洲特有毒株，与我国长期流行的  O 型、A 型、亚洲 1  型等毒株在基因组、衣壳结构、抗原蛋白组成及表位构象上存在本质区别，不同血清型间无交叉免疫保护，现有常规疫苗无法提供有效保护。

Recombinant  FMDV (SAT-1) VP1 Protein, N-His  (VK500132)是武汉艾必赛生物科技有限公司（abinScience）推出的一款高纯度、高免疫原性的重组病毒蛋白。该产品为口蹄疫病毒（FMDV）南非1型（SAT-1）的衣壳蛋白VP1，携带N端组氨酸（His）标签，采用大肠杆菌系统表达并纯化。VP1蛋白是口蹄疫病毒的主要衣壳蛋白和关键抗原，负责病毒与宿主细胞受体的结合，并能诱导机体产生中和抗体，是研究病毒致病机制、开发诊断试剂及亚单位疫苗的核心原料。

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

1. KIF5B-mediated internalization of FMDV promotes virus infection. PMID: 38499154

2. FMDV 3A Antagonizes the Effect of ANXA1 to Positively Modulate Viral Replication. PMID: 35604142

3. Cmss1 limits FMDV infection by enhancing antigen presentation and CD8(+) T cell responses. PMID: 41277842

4.  A review of foot-and-mouth disease virus (FMDV) testing in livestock  with an emphasis on the use of alternative diagnostic specimens. PMID:  30345947

5.  Foot-and-mouth disease virus (FMDV) negatively regulates ZFP36 protein  expression to alleviate its antiviral activity. PMID: 39194213

6. FMDV Leader Protein Interacts with the NACHT and LRR Domains of NLRP3 to Promote IL-1beta Production. PMID: 35062226

7. MicroRNA-4331-5p promotes FMDV replication through inhibiting interferon pathways in PK-15 cells. PMID: 32574680

8. Multiple-Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication. PMID: 36005757

9.  Ribosomal protein L35 negatively regulates FMDV replication by  recruiting AMFR to promote the ubiquitination and degradation of VP2.  PMID: 41065387

10.  3C(pro) of FMDV inhibits type II interferon-stimulated JAK-STAT  signaling pathway by blocking STAT1 nuclear translocation. PMID:  36921803

11. DDX56 cooperates with FMDV 3A to enhance FMDV replication by inhibiting the phosphorylation of IRF3. PMID: 31445188

12.  Small Molecules Targeting 3C Protease Inhibit FMDV Replication and  Exhibit Virucidal Effect in Cell-Based Assays. PMID: 37766293

13. Mutation of FMDV L(pro) H138 residue drives viral attenuation in cell culture and in vivo in swine. PMID: 36387381

14.  The Host Protein CAD Regulates the Replication of FMDV through the  Function of Pyrimidines' De Novo Synthesis. PMID: 37162335

15.  Enhanced antigen-specific CD8 T cells contribute to early protection  against FMDV through swine DC vaccination. PMID: 38289108

16. DDX21, a Host Restriction Factor of FMDV IRES-Dependent Translation and Replication. PMID: 34578346

17. RNA-Seq analysis reveals the different mechanisms triggered by bovine and equine after infection with FMDV. PMID: 39287214

18.  Assessment on Different Vaccine Formulation Parameters in the  Protection against Heterologous Challenge with FMDV in Cattle. PMID:  36016403

19. Development of a competitive ELISA method based on VLPs detecting the antibodies of serotype A FMDV. PMID: 34915087

20. Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV. PMID: 40733501

21. Susceptibility of primary ovine dorsal soft palate and palatine tonsil cells to FMDV infection. PMID: 39149149

22. Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. PMID: 25835532

23.  Development and Validation of Serotype-Specific Blocking ELISA for the  Detection of Anti-FMDV O/A/Asia1/SAT2 Antibodies. PMID: 39339914

24.  A genome-wide CRISPR screening uncovers that TOB1 acts as a key host  factor for FMDV infection via both IFN and EGFR mediated pathways. PMID:  38512977

25.  Unrecognized circulation of SAT 1 foot-and-mouth disease virus in  cattle herds around Queen Elizabeth National Park in Uganda. PMID:  26739166

26. Foot-and-mouth disease virus serotype SAT1 in cattle, Nigeria. PMID: 28224715

27.  Meta-analysis of genetic diversity of VP1 gene of foot and mouth  disease virus serotypes prevalent in Bangladesh from 2010 to 2024. PMID:  41043698

28. The role of African buffalos (Syncerus caffer) in the maintenance of foot-and-mouth disease in Uganda. PMID: 21143994

29.  Differentiation of the seven serotypes of foot-and-mouth disease virus  by reverse transcriptase polymerase chain reaction. PMID: 9274816

30.  Characterization of foot-and-mouth disease viruses (FMDVs) from Ugandan  cattle outbreaks during 2012-2013: evidence for circulation of multiple  serotypes. PMID: 25664876

31.  Characterisation of recent foot-and-mouth disease viruses from African  buffalo (Syncerus caffer) and cattle in Kenya is consistent with  independent virus populations. PMID: 25644407

32. Molecular Characterization of Foot-and-Mouth Disease Viruses Collected in Tanzania Between 1967 and 2009. PMID: 24460931

33.  Pervasive within-host recombination and epistasis as major determinants  of the molecular evolution of the foot-and-mouth disease virus capsid.  PMID: 31905219

34.  Analysis of Recent Serotype O Foot-and-Mouth Disease Viruses from  Livestock in Kenya: Evidence of Four Independently Evolving Lineages.  PMID: 23931583

35. Capsid protein-encoding (P1) sequence of foot and mouth disease virus type Asia 1 ind 63/72. PMID: 10403702

36. Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases. PMID: 12036580

37.  Demonstration of antigenic site 3 in foot-and-mouth disease virus  serotype A using neutralizing monoclonal antibody resistant mutants.  PMID: 41456690

38. Evidence for positive selection in foot-and-mouth disease virus capsid genes from field isolates. PMID: 11139487

39.  Development and evaluation of tailored specific real-time RT-PCR assays  for detection of foot-and-mouth disease virus serotypes circulating in  East Africa. PMID: 27575682

详情请咨询 abinScience 亚洲区官方子公司 —— 武汉艾必赛生物技术有限公司

官方网址：【中文】https://www.abinscience.cn

【英文】https://www.abinscience.com

武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。

依托严格的产品研发体系和国际化的质量管理标准，武汉艾必赛与 AtaGenix、ProteoGenix 等知名品牌保持长期战略合作，现已构建起涵盖抗体、重组蛋白、工具酶、试剂盒、实验耗材在内的多品类供应体系，面向区域内科研机构、高校实验室与生物医药企业，提供稳定、高效、可信赖的产品与服务。

核心业务覆盖：
✅ 抗体产品（单抗、多抗、重组抗体等）
✅ 蛋白与多肽试剂（标签蛋白、功能蛋白等）
✅ 分子与细胞实验相关耗材
✅ 定制化研发服务（蛋白表达、抗体定制、亲和力成熟等）
✅ 科研供应链整合与项目配套支持

武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。