Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Sulindac(38194-50-2)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Sulindac
Synonyms
(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-[(p-methylsulfinyl)benzylidenyl]indene-3-acetic acid
CAS
38194-50-2
Formula
C20H17FO3S
Molecular Weight
356.42
EINECS
253-819-2
RTECS
NK8226000
RTECS Class
Drug; Reproductive Effector; Human Data
Merck
12,9155
Beilstein/Gmelin
2951842
Beilstein Reference
6-10

Physical and Chemical Properties

Solubility in water
Insoluble
Melting Point
195
Boiling Point
582
Vapor Pressure
2E-14 (25 C)
pKa/pKb
4.22 (pKa)
Partition Coefficient
3.42
Heat Of Vaporization
91.5 kJ/mol
Usage
Nonsteroidal anti-inflammatory; preferential inhibitor of cox-1.

First Aid Measures

Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage
Keep tightly closed.

Hazards Identification

Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Skin
May cause skin irritation. May be harmful if absorbed through the skin.
Eyes
May cause eye irritation.
Ingestion
Harmful if swallowed.
Hazards
Emits toxic fumes under fire conditions.
EC Risk Phrase
22

Exposure Controls/Personal Protection

Personal Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Exposure Effects
Toxic if swallowed. Target organ(s): Liver. G.I. System.

Fire Fighting Measures

Flash Point
306
Fire Fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Sulfur oxides, Hydrogen fluoride.
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