| Name | Urethane |
| Description | Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes. |
| In vitro | urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors[3]. |
| In vivo | Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems[2]. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics[3]. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity[1]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (617.35 mM), Sonication is recommended.
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| Keywords | α4β2 nAChR | Urethane | Pesticide | Parasite | NMDA receptor | narcosis | mutagen | Inhibitor | inhibit | Glycine receptor | GABAReceptor | GABAR | GABA Receptor | clastogen | Chloridechannel | Chloride channel | carbamic | Bacterial | AMPA | acid |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Kojic acid | Methyl anthranilate | Kanamycin sulfate | p-Hydroxybenzaldehyde | Sulfamethoxazole sodium | Hydroxychloroquine | Doxycycline | Isoeugenol | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Natural Product Library | Drug Repurposing Compound Library | Antiparasitic Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Ion Channel Targeted Library | Anti-Cancer Drug Library |
United States
