Trichlormethiazide

$ 10.00 /1kg

Min. Order1kg
Purity99%
Cas No133-67-5
Supply AbilityEx 20 tons
Update time2022-10-11

Hebei Anda Technology Co., LTD

2YR

China

Chemical Properties

Product Name	Trichlormethiazide
CAS No	133-67-5
EC-No	205-118-8
Min. Order	1kg
Purity	99%
Supply Ability	Ex 20 tons
Release date	2022/10/11

Use of Trichlormethiazide

Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide.Target: OthersTrichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic [1-3].

Name	Trichlormethiazide
Synonym	More Synonyms

Description	Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide.Target: OthersTrichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic [1-3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease
Solvent	In Vitro: DMSO : 150 mg/mL (394.05 mM; Need ultrasonic) In Vivo: 1.Add each solvent one by one: 10% DMSO 90% corn oil Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution 2.Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution 3.Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution
Solubility	1 mM2.6270 mL13.1351 mL26.2702 mL5 mM0.5254 mL2.6270 mL5.2540 mL10 mM0.2627 mL1.3135 mL2.6270 mL
Storage	4°C, protect from light
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	O=S(C1=C(Cl)C=C(C2=C1)NC(C(Cl)Cl)NS2(=O)=O)(N)=O
References	[1]. Fuchs, M., B.E. Newman, and R.H. Seller, The clinical pharmacology of trichlormethiazide (Naqua). Curr Ther Res Clin Exp, 1961. 3: p. 116-24. [2]. Reisman, E.E., Jr., Clinical experience with trichlormethiazide in edema. Angiology, 1963. 14: p. 59-63. [3]. West, R.O., A clinical and statistical study of the effect of trichlormethiazide on blood pressure. Med Ann Dist Columbia, 1962. 31: p. 574-7.
Related Molecules	EIPA \| Riluzole \| Ginsenoside Rg3 \| Cariporide \| Eleclazine hydrochloride \| GS967 \| Tenapanor \| Triamterene \| Ranolazine dihydrochloride \| PF 05089771 \| flecainide acetate \| A-803467 \| CNV1014802 (hydrochloride) \| Zonisamide \| Cinchocaine

Density	1.7±0.1 g/cm3
Boiling Point	631.3±65.0 °C at 760 mmHg
Melting Point	248-250ºC
Molecular Formula	C8H8Cl3N3O4S2
Molecular Weight	380.656
Flash Point	335.6±34.3 °C
Exact Mass	378.902191
PSA	135.12000
LogP	0.24
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.625