Tianeptine Sodium Salt

$ 10.00 /1kg

Min. Order1kg
Purity99%
Cas No30123-17-2
Supply AbilityEx 20 tons
Update time2022-10-11

Hebei Anda Technology Co., LTD

3YR

China

Chemical Properties

Product Name	Tianeptine Sodium Salt
CAS No	30123-17-2
EC-No	250-059-3
Min. Order	1kg
Purity	99%
Supply Ability	Ex 20 tons
Release date	2022/10/11

Use of Tianeptine Sodium Salt

Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo

Name	Tianeptine sodium salt hydrate
Synonym	More Synonyms

Description	Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
Solvent	In Vitro: H2O : ≥ 235 mg/mL (512.06 mM) * "≥" means soluble, but saturation unknown.
Solubility	1 mM2.1790 mL10.8949 mL21.7898 mL5 mM0.4358 mL2.1790 mL4.3580 mL10 mM0.2179 mL1.0895 mL2.1790 mL
Storage	Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 month
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	O=C(CCCCCCNC(C1=CC=CC=C1N2C)C3=CC=C(C=C3S2(=O)=O)Cl)[O-].[Na+]
References	[1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20. [2]. Orescanin-Dusic Z, et al. Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction. Acta Physiol Hung. 2012 Jun;99(2):140-7. [3]. Della FP, Abelaira HM, Réus GZ, Ribeiro KF, Antunes AR, Scaini G, Jeremias IC, Dos Santos LM, Jeremias GC, Streck EL, Quevedo J.Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.Behav Brain Res. 2012 Aug 1;233(2):526-35. Epub 2012 May 31. [4]. Sohn W, Lee OY, Kwon JG, Park KS, Lim YJ, Kim TH, Jung SW, Kim JI.Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.Neurogastroenterol Motil. 2012 Sep;24(9):860-e398. [5]. Orola L, Veidis MV, Sarcevica I, Actins A, Belyakov S, Platonenko A.The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.Int J Pharm. 2012 Aug 1;432(1-2):50-6. Epub 2012 Apr 30.
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Density	1.38 g/cm3
Boiling Point	609.2ºC at 760 mmHg
Melting Point	1800C
Molecular Formula	C21H24ClN2NaO4S
Molecular Weight	458.934
Flash Point	322.2ºC
Exact Mass	458.104309
PSA	97.92000
LogP	4.39460
Storage condition	Desiccate at RT