| Name | Tolperisone hydrochloride |
| Description | Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyelitis, myelopathy, multiple sclerosis, pyramidal tract) and of spastic paralysis and other encephalopathies manifested with muscular dystonia. |
| In vivo | Tolperisone hydrochloride is a safe and effective drug for the treatment of pain-reflex muscle spasms without the typical side effects of central muscle relaxants.Tolperisone blocks calcium ion flow in snail neurons, decreases sodium-potassium ion permeability at frog Lang's ganglion, and has an current passage through Nav1.6 channels (heterologous expression) Inhibitory effect on current through Nav1.6 channel (heterologous expression). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (195.16 mM), Sonication is recommended.
Ethanol : 52 mg/mL (184.51 mM), Sonication is recommended.
H2O : 51 mg/mL (180.97 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.1 mM), Sonication is recommended.
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| Keywords | Tolperisone hydrochloride | Tolperisone Hydrochloride | Tolperisone | SodiumChannel | Sodium Channel | Inhibitor | inhibit |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Phenytoin sodium | Sodium 4-phenylbutyrate | Metronidazole | Citric Acid Triammonium | Tributyrin | L-Methionine | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Approved Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Drug-Fragment Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
United States
