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3644-61-9

Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Hazard Information Spectrum Detail Well-known Reagent Company Product Information

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Identification

Name
Tolperisone hydrochloride
CAS
3644-61-9
Synonyms
2,4'-dimethyl-3-piperidinopropiophenone
2,4'-DIMETHYL-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE
2,4'-dimethyl-3-piperidinopropiophenone monohydrochloride
2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone
4'-METHYL-2-(1-PIPERIDINYLMETHYL)-PROPIOPHENONE HCL
4'-methyl-2-(1-piperidinylmethyl)-propiophenone hydrochloride
LABOTEST-BB LT00772344
TOLPERISONE HCL
TOLPERISONE HYDROCHLORIDE
1-piperidino-2-methyl-3-(p-tolyl)-3-propanonehydrochloride
2,4’-dimethyl-3-piperidino-propiophenonhydrochloride
2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanonhydrochloride
2-methyl-3-piperidino-1-p-tolylpropan-1-onehydrochloride
midocalm
muscalm
mydocalm
n-553
1-Piperidino-2-methyl-3-(4-methylphenyl)propan-3-one hydrochloride
1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI)
Abbsa
EINECS(EC#)
222-876-5
Molecular Formula
C16H24ClNO
MDL Number
MFCD00058211
Molecular Weight
281.82
MOL File
3644-61-9.mol

Chemical Properties

Appearance
White Solid
Melting point 
181-183°C
mp 
181-183°C
storage temp. 
Room temp
solubility 
H2O: >20mg/mL
form 
solid
color 
white
PH
pH(50g/l, 25℃) : 4.5~5.5
Water Solubility 
almost transparency
Usage
Used as a muscle relaxant
Merck 
9522
CAS DataBase Reference
3644-61-9(CAS DataBase Reference)

Safety Data

Hazard Codes 
Xn,Xi
Risk Statements 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37:Wear suitable protective clothing and gloves .
S37/39:Wear suitable gloves and eye/face protection .
WGK Germany 
3
RTECS 
UH1575500
Toxicity
LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961)

Raw materials And Preparation Products

Hazard Information

Chemical Properties
White Solid
Originator
Tolperisone hydrochloride,Shanghai Abochem Chemical Co.
Uses
Tolperisone hydrochloride can be used as a muscle relaxant.
Manufacturing Process
To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.
Therapeutic Function
Muscle relaxant, Vasodilator

Spectrum Detail

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