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Tolperisone hydrochloride

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Tolperisone hydrochloride Basic information
Tolperisone hydrochloride Chemical Properties
  • Melting point:181-183°C
  • storage temp. Room temp
  • solubility H2O: >20mg/mL
  • form solid
  • color white
  • PHpH(50g/l, 25℃) : 4.5~5.5
  • Water Solubility almost transparency
  • Merck 14,9522
  • CAS DataBase Reference3644-61-9(CAS DataBase Reference)
Safety Information
Tolperisone hydrochloride Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • OriginatorTolperisone hydrochloride,Shanghai Abochem Chemical Co.
  • UsesTolperisone hydrochloride can be used as a muscle relaxant.
  • Manufacturing ProcessTo 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.
  • Therapeutic FunctionMuscle relaxant, Vasodilator
Tolperisone hydrochloride Preparation Products And Raw materials
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