Thymosin alpha-1

Thymosin alpha-1 is an immunomodulatory polypeptide belonging to the group of thymic hormones. It is produced endogenously by the thymus gland and increases T cell-mediated immune responses by several mechanisms, including stimulation of T-cell differentiation and/or maturation, activation of natural killer cells and dendritic cells, and stimulation of proinflammatory cytokine release.

thymosin alpha-1 could potentiate the efficacy of dacarbazine. The addition of thymosin alpha-1 to dacarbazine and interferon-alfa did not lead to any additional adverse reactions.