This product has been converted to 5α dihydrotestosterone (5α-dihyrotesterone) in body and then binds to the cell receptor and into the nucleus to interact with chromatin and activate RNA polymerase to promote protein synthesis and cell metabolism. In addition, testosterone propionate stimulates erythrocyte production and differentiation through erythropoietin. This product can be absorbed by oral administration, but it will be destroyed rapidly in the liver and ineffective, so intramuscular injection is generally used. After intramuscular injection of testosterone propionate, the absorption is slow, and its delayed effect time is 2-4 days. In the blood, 98% of testosterone is bound to the sex hormone globulin and only 2% is free. The half-life is 10-20 minutes. After the inactivation of testosterone in the liver, the metabolites are androsterone isoandrosterone and procholanolone. 90% of them are excreted from the urine in combination with uronic acid and sulfuric acid. About 6% of uncombined products are excreted by bile, of which a small part can be reabsorbed to form enterohepatic circulation.
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