| Name | TC ASK 10 |
| Description | TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM. |
| In vitro | Streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM inhibited by TC ASK 10 (0-10 μM; 1 hour; INS-1 cells). Phosphorylation of p38 is also inhibited in a dosedependent manner. |
| In vivo | In rats, Pharmacokinetic profiles are tested. TC ASK 10 (rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (231.29 mM)
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| Keywords | Apoptosis | ASK1 | oral | MAP3K | bioavailability | TC ASK-10 | TC ASK10 | TC ASK 10 | Inhibitor | pharmacokinetic | JNK | p38 | inhibit | selective | MAP kinase kinase kinase, MEKK, MAPKKK | Phosphorylation |
| Inhibitors Related | Sodium lauryl sulfoacetate | Nomilin | Vemurafenib | CMPD1 | SKLB-163 | MBM-55S | sodium lauroyl-α-hydroxyethyl sulfonate | NQDI-1 | Takinib | NG25 | MK2-IN-3 hydrate | Selonsertib |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Pyroptosis Compound Library | Inhibitor Library | Anti-Prostate Cancer Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library |
United States
