Name | TC ASK 10 |
Description | TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM. |
In vitro | Streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM inhibited by TC ASK 10 (0-10 μM; 1 hour; INS-1 cells). Phosphorylation of p38 is also inhibited in a dosedependent manner. |
In vivo | In rats, Pharmacokinetic profiles are tested. TC ASK 10 (rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 100 mg/mL (231.29 mM), Sonication is recommended.
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Keywords | TC ASK-10 | TC ASK10 | TC ASK 10 | selective | Phosphorylation | pharmacokinetic | p38 | oral | MAP3K | MAP kinase kinase kinase, MEKK, MAPKKK | JNK | Inhibitor | inhibit | bioavailability | ASK2 | ASK1 | Apoptosis |
Inhibitors Related | Sodium lauryl sulfoacetate | Nomilin | CMPD1 | Vemurafenib | SKLB-163 | MBM-55S | sodium lauroyl-α-hydroxyethyl sulfonate | RV01 | Takinib | NG25 | RMM-46 | Selonsertib |
Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Pyroptosis Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | MAPK Inhibitor Library |