名称 | TC-MCH 7c |
描述 | TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM. |
体外活性 | In [Ca2+]i mobilization, TC-MCH 7c has an IC50 of 9.7 μM for MCH1R [1]. TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively[2]. |
体内活性 | In DIO mice model, TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) shows excellent body weight reduction in a dose-dependent manner [1]. TC-MCH 7c(oral; 3 to 30mg /kg) and 30mg /kg at 2, 15 and 24 h were 5.1, 1.8 and 0.7 μM, respectively[2]. |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | 1eq. HCl : 36.8 mg/mL (90.0 mM) DMSO : 55 mg/mL (134.65 mM), Sonication is recommended.
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关键字 | TC-MCH 7c | TCMCH 7c | TC MCH 7c |
相关产品 | MCH(human, mouse, rat) | MCHR1 antagonist 2 | ATC 0175 hydrochloride | SNAP 94847 | Melanin Concentrating Hormone, salmon acetate | Neuropeptide EI, rat acetate | PG 931 acetate | SNAP 94847 hydrochloride | [Ala17]-MCH acetate |
相关库 | 经典已知活性库 | 膜蛋白靶向化合物库 | 抑制剂库 | 口服活性化合物库 | 已知活性化合物库 | 含氟化合物库 | GPCR靶点分子库 | 抗癌化合物库 |