TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) exhibits excellent body weight reduction in a dose-dependent manner in DIO mice model[1].
TC-MCH 7c (oral; 3-30 mg/kg) with 30 mg/kg has plasma concentrations of 5.1, 1.8, and 0.7 μM at 2, 15, and 24 hours, respectively[2].
| Animal Model: | C57BL/6J DIO mice[1] |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | Oral; once-daily for 1.5 months |
| Result: | Exhibited excellent body weight reduction in a dose-dependent manner.
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| Animal Model: | Diet-induced obesity mice[2] |
| Dosage: | 3, 10 and 30 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Oral |
| Result: | Plasma concentrations at 2, 15, and 24 hours were 5.1, 1.8, and 0.7 μM, respectively.
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