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ChemicalBook Product Catalog Sugammadex sodium

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Sugammadex sodium NEW

$34.00 5mg

$54.00 10mg

$86.00 25mg

Min. Order
Purity99.44%
Cas No343306-79-6
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Sugammadex sodium
CAS No	343306-79-6
EC-No
Min. Order
Purity	99.44%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Sugammadex sodium
Description	Sugammadex sodium (Org25969) , a synthetic derivative of γ-cyclodextrin, is a steroid-based neuromuscular blocker reversing agent.
Animal Research	The animals were anesthetized with 80 mg/kg ketamine hydrochloride and 12 mg/kg xylazine administered intraperitoneally. After the rats were anesthetized, the bilateral common carotid arteries were exposed and carefully separated from the carotid sheath and the cervical sympathetic and vagal nerves through a ventral cervical incision. The bilateral common carotid arteries were occluded with nontraumatic aneurysm clips in ischemic rats but were not clamped in sham-operated rats. Complete interruption of the blood flow was confirmed by observing the central artery in the retina with an ophthalmoscope. The body temperature of the rats was maintained at 37.0 ± 0.5°C during this procedure. In this model, 10 minutes of ischemia and 24 hours of reperfusion were induced. After the ischemic period, the rats were treated with sugammadex 16 mg/kg (S 16 group) and sugammadex 100 mg/kg (S 100 group) (intravenous and total volume 1 mL) in the 5th minute of reperfusion. Sugammadex was diluted with normal saline (0.9% NaCl). The same surgical procedure was performed in the I/R group, but the rats were not treated with sugammadex. The neck incision was closed with sutures (3.0 silk), and the animals were allowed to awaken. After 24 hours, the neurological condition of the rats was assessed with a scoring system [2].
In vivo	Injection of 100 microg/kg rocuronium resulted in a mean neuromuscular blockade of 93.0%, and profound blockade was achieved by injection of 500 microg/kg. After injection of the high rocuronium dose, the 90% recovery of the train-of-four ratio took 28 min after saline, 26 min after 1 mg/kg sugammadex, and 8 min after 2.5 mg/kg sugammadex. Signs of residual blockade or recurarization were not observed [1]. Treatment with 16 mg/kg and 100 mg/kg sugammadex had a neuroprotective effect in a transient global cerebral I/R rat model. However, 100 mg/kg sugammadex was more neuroprotective in rats [2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : 34 mg/mL (15.61 mM)
Keywords	inhibit \| Inhibitor \| anesthesia \| Sugammadex \| Org 25969 \| reversal agent \| neuromuscular block \| Sugammadex sodium \| ischemic \| Org-25969 \| Neuroprotective
Related Compound Libraries	Macrocyclic Compound Library \| NO PAINS Compound Library

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