| 名称 | SC75741 |
| 描述 | SC75741 is a potent P65 inhibitor with IC50 of 200 nM |
| 细胞实验 | Cell viability assay is prepared using a CellTiter-BluTM Cell Viability Assay. For each concentration of the compound four replicates are measured.(Only for Reference) |
| 激酶实验 | NF-κB reporter gene assay: The NF-κB reporter gene assay is prepared with A549-NF-κB-SEAP cell line according to manufacturer's instructions. In short, A549 cells stably transfected with pNF-κB-SEAP reporter gene plasmid are plated and allowed to attach overnight. The cells are subsequently incubated for 5 h with described compounds at 100, 30, 10, 3, 1, 0.3, 0.1, and 0 μM and then stimulated with 10 ng/ml TNF-α for 22 h. The supernatant of the cell is analyzed for SEAP activity using a chemiluminescent SEAP reporter gene assay. |
| 体外活性 | SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. [1] SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants. [2] |
| 体内活性 | SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection. [2] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 50 mg/mL (88.39 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| 关键字 | SC-75741 | inhibit | Inhibitor | Nuclear factor-kappaB | Influenza Virus | SC 75741 | Nuclear factor-κB | NF-κB | SC75741 |
| 相关产品 | Rifampicin | Acetylcysteine | Nitazoxanide | Diethylmaleate | Curcumin | Glucosamine | Lidocaine hydrochloride | Naringenin | Indole-3-carbinol | Diallyl disulfide | Salcomine | Crystal Violet |
| 相关库 | NF-κB 通路分子库 | 抗胰腺癌化合物库 | 经典已知活性库 | 抗病毒库 | 抑制剂库 | 抗前列腺癌化合物库 | 抗衰老化合物库 | 已知活性化合物库 | 抗癌活性化合物库 | 转录因子库 |
United States
