| Name | S-Adenosyl-L-methionine disulfate tosylate |
| Description | S-Adenosyl-L-methionine disulfate tosylate is a methyl donor with oral activity. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with effective antidepressant and pain-relieving effects. S-Adenosyl-L-methionine disulfate tosylate also has anti-proliferative, pro-apoptotic and anti-metastatic effects in cancer. S-Adenosyl-L-methionine can be used in the research of liver diseases and osteoarthritis. |
| In vitro | METHODS: Cal-33 and JHU-SCC-011 cells were treated with S-Adenosyl-L-methionine disulfate tosylate (300 µM) for 24 or 48 hours. Apoptosis and cell cycle were detected by flow cytometry. Cell migration was detected using the Scratch-wound assay.
RESULTS: S-Adenosyl-L-methionine disulfate tosylate induces apoptosis and promotes cell cycle arrest in Cal-33 and JHU-SCC-011 cells, reducing the migration of Cal-33 and JHU-SCC-011 cells. [1]
METHODS: Human A549 lung cancer cells were treated with S-Adenosyl-L-methionine disulfate tosylate (5-40 μg/mL) for 48 hours, and the DNMTs protein level was detected by Western Blot method.
RESULTS: S-Adenosyl-L-methionine disulfate tosylate protects the anti-cancer effect of 5-FU by regulating the expression of DNMTs. [2] |
| In vivo | METHODS: To investigate the effect of S-Adenosyl-L-methionine disulfate tosylate on ASD, S-Adenosyl-L-methionine disulfate tosylate (30 mg/kg) was administered orally to young rats for 3 days.
RESULTS: S-Adenosyl-L-methionine disulfate tosylate could prevent ASD-like behaviors induced by valproic acid exposure early after birth in young rats. [3]
METHODS: To study the antiepileptic effect of S-Adenosyl-L-methionine disulfate tosylate, S-Adenosyl-L-methionine disulfate tosylate (50 mg/kg, 100 mg/kg) was orally administered to pentylenetetrazole-induced epilepsy rats.
RESULTS: S-Adenosyl-L-methionine disulfate tosylate exhibited antiepileptic, memory enhancement and antioxidant properties in pentylenetetrazole-induced epilepsy rats. [4] |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : 72 mg/mL (93.9 mM), Sonication is recommended.
DMSO : 247.5 mg/mL (322.77 mM), Sonication is recommended.
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| Keywords | S-Adenosyl-L-methionine disulfate Tosylate | SAdenosylLmethionine disulfate tosylate | S-Adenosyl methionine disulfate | S Adenosyl L methionine disulfate tosylate | RNASynthesis | RNA Synthesis | Inhibitor | inhibit | DNASynthesis | DNA Synthesis | APE1(Ref-1) | AdoMet disulfate | Ademetionine disulfate Tosylate | Ademetionine disulfate |
| Inhibitors Related | 5-Fluorouracil | Quinizarin | Adenine hemisulfate | Procaine | Rifaximin | Capecitabine | Ribavirin | Guanidine hydrochloride | Methotrexate disodium | Thymidine | Cisplatin | Folic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Drug Repurposing Compound Library | Natural Product Library for HTS | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
