Chemical Properties
White to off-white powder
Uses
Ademetionine Disulfate Tosylate is used to study the survival time in various damage brain models.
Application
S-Adenosyl-L-methionine Disulfate Tosylate (SAMe-ST) is the tosylate disulphate form of S-adenosyl-L-methionine (SAM). SAM may serve as an adjunctive therapy for refractory major depressive disorder. SAMe-ST is a multifunctional biochemical agent exhibiting antidepressant, anticancer and hepatoprotective properties. It may be administered as a dietary supplement for the management of depressive disorders and hepatic conditions.
Definition
The density of Ademethionine Disulfate Tosylate is typically between 1.42-1.48 g/cm3. Its unique characteristics make it an ideal compound for various health supplements and pharmaceuticals. The compound is commonly packaged in sealed containers and transported at controlled temperatures to ensure its integrity and purity. It is manufactured through synthetic procedures involving the reaction between adenosine triphosphate (ATP) and methionine. Ademethionine Disulfate Tosylate is typically used for its therapeutic effects, which range from improving liver function to providing relief from depression and arthritis. It is used extensively in treating liver diseases and is known to enhance liver cell regeneration, promote bile flow, and improve overall liver function. SAMe is also known for its anti-inflammatory properties, which make it effective in reducing the symptoms of conditions such as osteoarthritis and depression.
Biosynthesis
Ademethionine Disulfate Tosylate (SAME) is made in the body from methionine, an amino acid found in foods.
Biological Activity
Studies have shown that S-adenosyl-L-methionine disulfate tosylate salt (SAMe-ST) at concentrations of 0.2 to 5.0 mg/ml protects red blood cells from hypotonic hemolysis, and that this protection is attributed to the SAMe moiety itself, rather than its Sulfate or mesylate moiety. SAMe-ST significantly increased Na+.K(+)-ATPase activity[1].
Side effects
Ademethionine Disulfate Tosylate is likely safe. Side effects might include gas, diarrhea, constipation, dry mouth, headache, and nervousness, especially at higher doses.
References
[1] M TSUJI;K O;K Kodama. Protective effects of S-adenosyl-L-methionine against enzyme leakage from cultured hepatocytes and hypotonic hemolysis.[J]. Japanese journal of pharmacology, 1990. DOI:10.1254/jjp.52.45.
