| Name | Rocuronium bromide |
| Description | Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation. |
| In vitro | Rocuronium effectively reduces indirectly elicited twitch tensions in both normal diaphragms (IC50: 9.84 μM) and those pretreated, showing a significant decrease (P < .01, n = 6) in a concentration-dependent manner [1]. It exhibits a similar ED95 for both children and adults, with a duration of action comparable to vecuronium but is shorter in children. Conventional doses of cholinesterase inhibitors can readily reverse its effects [2]. The onset time for maximum block is 1.7 (32) minutes, with the duration until 25% recovery of twitch height at 53 (19) minutes, and recovery from 25% to 75% of twitch height taking 20 (37) minutes [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 113 mg/mL (185.34 mM), Sonication is recommended.
H2O : 112 mg/mL (183.7 mM), Sonication is recommended.
Ethanol : 113 mg/mL (185.34 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 3.3 mg/mL (5.41 mM), Sonication is recommeded.
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| Keywords | Rocuronium Bromide | Rocuronium | ORG-9426 | ORG9426 | mAChR | Inhibitor | inhibit |
| Inhibitors Related | Adiphenine hydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Clozapine N-Oxide | Urethane | Ribavirin | Adenine | Mitotane | Choline chloride | Propoxur | N,N-Dicyclohexylcarbodiimide | Arecoline | Xanomeline tartrate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | NMPA-Approved Drug Library |
United States
