Phentolamine mesilate

Phentolamine mesilate is vasodilator drug CAS:65-28-1

As an adrenergic blocking agent and an antihypertensive, Phentolamine mesilate can be used for the treatment of pheochromocytoma.
The primary application for phentolamine is for the control of hypertensive emergencies, most notably due to pheochromocytoma.
It also has usefulness in the treatment of cocaine-induced cardiovascular complications, where one would generally avoid β-blockers, as they can cause unopposed α-adrenergic mediated coronary vasoconstriction, worsening myocardial ischemia and hypertension. 
It is important to note that phentolamine is not a first-line agent for this indication.
When given by injection it causes blood vessels to dilate, thereby increasing blood flow. When injected into the penis(intracavernosal), it increases blood flow to the penis, which results in an erection.
It may be stored in crash carts to counteract severe peripheral vasoconstriction secondary to extravasation of peripherally placed vasopressor infusion, typically of norepinephrin. Epinephrin infusion are less vasoconstrictive than norepinephrin as they primarily stimulate β receptor more than α receptors, but the effect remains dose-dependent.
Phentolamine also has diagnostic and therapeutic roles in complex regional pain syndrome (reflex sympathetic dystrophy).

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