| CAS: | 63-92-3 |
| MF: | C18H22ClNO.ClH |
| MW: | 340.29 |
| EINECS: | 200-569-7 |
| Product Categories: | DIBENZYLINE;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 63-92-3.mol |
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| Phenoxybenzamine hydrochloride Chemical Properties |
| Melting point | 137.5°C |
| storage temp. | 15-25°C |
| solubility | soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). |
| pka | pKa 4.4 (Uncertain) |
| form | powder |
| color | white |
| Water Solubility | <0.01 g/100 mL at 18.5 ºC |
| Merck | 14,7256 |
| Stability: | Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 63-92-3(CAS DataBase Reference) |
| IARC | 2B (Vol. 24, Sup 7) 1987 |
| EPA Substance Registry System | N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride (63-92-3) |
| Phenoxybenzamine hydrochloride Usage And Synthesis |
| Description | Phenoxybenzamine hydrochloride (dibenzyline) is an orally effective, long-acting non-selective (alpha1 and alpha2) alpha-adrenoceptor blocking agent. It is used for the control of episodes of hypertension associated withpheochromocytoma. It literally produces a "chemical sympathectomy". It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. The initialdose is 10 mg/day, increased by 10 mg every 4 days till the desired response is attained.The usual dosage range is 20-60mg/day. |
| Chemical Properties | white crystalline solid or powder. Odorless. soluble in ethanol, chloroform, propylene glycol, slightly soluble in benzene, slightly soluble in cold water. The melting point of its free base is 38-40 ° C, and it is soluble in benzene. |
| Originator | Dibenzyline, SKF, US ,1953 |
| Uses | Phenoxybenzamine is used in treating pheochromocytoma, swelling of the medullary layer of the adrenal glands, during which a large quantity of epinephrine is produced, which leads to a significant elevation of blood pressure. |
| Uses | Phenoxybenzamine (5.0 to 60.0 mg/day) is used in order to control episodes of hypertension and sweating, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers. If tachycardia is excessive, it may also be necessary to use a betablocker concomitantly. In addition, phenoxybenzamine has been tested for its efficacy in micturition disorders resulting from neurogenic bladder, functional outlet obstruction, and partial prostatic obstruction. |
| Definition | ChEBI: Phenoxybenzamine hydrochloride is an organic molecular entity. |
| Brand name | Dibenzyline (WellSpring). |
Product picture
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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