Product Description
Product name: Oseltamivir phosphate
CAS No.: 204255-11-8
Molecular formula: C16H31N2O8P
Molecular weight: 410.4
Melting point: 196-198°C
Oseltamivir Phosphate is the phosphate salt of oseltamivir, a synthetic derivative prodrug of ethyl ester with antiviral activity.By blocking neuraminidases on the surfaces of influenza viruses, oseltamivir interferes with host cell release of complete viral particles.
Oseltamivir Phosphate used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Function
Oseltamivide phosphate is rapidly metabolized to oseltamivir carboxylate by absorption through the gastrointestinal tract and at least 75% of the oral dose is involved in systemic circulation in the form of oseltamivir carboxylate.
The active ingredient Is a potent and unique neuraminidase inhibitor that acts on all aspects of influenza virus infection and prevents the replication of all clinically relevant strains of influenza A or B viruses. In vitro in very low nanomolar concentrations that have inhibitory effect.
The active metabolite was observed to inhibit the growth of influenza virus in vitro and it was also observed in vivo to inhibit the replication and pathogenicity of influenza virus.
Oseltamivide phosphate reduces the spread of influenza A or B viruses by inhibiting the release of the virus from the infected cells.
Application
Oseltamivir phosphate is used for the prevention and treatment of influenza caused by influenza A and B viruses.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.Oseltamivir's risk-benefit ratio is controversial.
Oseltamivide phosphate is an anti-influenza virus drug, trade name Tamiflu,white to yellow-white powder appearance can be divided into A (A) and B (B) influenza virus nerve ammonia Acidase-selective inhibitors,by inhibiting the virus neuraminidase to stop the virus from being infected cells and disseminated, so as to achieve the purpose of controlling flu symptoms. Clinically for the prevention of influenza A and B influenza in adults and children aged 1 and over,adults and adults 13 and over 13 years of age.
China
