| Name | Oseltamivir phosphate |
| Description | Oseltamivir phosphate (GS 4104) is a neuraminidase (NA) inhibitor with oral activity. Oseltamivir phosphate has antiviral activity and is effective against a wide range of influenza viruses, inhibiting mature influenza viruses from breaking away from host cells. |
| Cell Research | Cells are incubated in 96-well plates (5,000 cells/well) and allowed to adhere for 24 hours in 1× DMEM media containing 10% FCS. The media are replaced with fresh DMEM media containing 5% FCS with or without various concentrations of tamoxifen or OP for indicated time periods. Cell viability is tested using WST-1 cell proliferation assay.(Only for Reference) |
| In vitro | METHODS: Preparation of D-Luciferin potassium for in vitro bioluminescence analysis:
1. Prepare 200× D-Luciferin reserve solution (30 mg/mL) with sterile water and mix gently until all dissolved. It can be used immediately after preparation or stored at -20℃.
2. Prepare 1× D-Luciferin (150 µg/mL) working solution in preheated tissue culture medium.
3. Aspirate the medium from the cultured cells.
4. Add 1× D-Luciferin solution to the cells before imaging. Incubate the cells at 37°C for a short period of time before imaging to increase signal. |
| In vivo | For in vivo experiments at higher doses, D-Luciferin potassium (T4139) or D-Luciferin Sodium (T19743) are recommended. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10 mg/mL (24.37 mM)
H2O : 80 mg/mL (194.93 mM), Sonification is recommended.
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| Keywords | Influenza Virus | GS4104 | Oseltamivir Phosphate | inhibit | Oseltamivir | Oseltamivir phosphate | GS-4104 | Inhibitor |
| Inhibitors Related | Rifampicin | Acetylcysteine | α-Vitamin E | Nitazoxanide | Curcumin | N-Acetylneuraminic acid | Naringenin | Salcomine | Crystal Violet | β-Cyclodextrin |
| Related Compound Libraries | Bioactive Compound Library | Drug-induced Liver Injury (DILI) Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-COVID-19 Compound Library |
United States
