| CAS: | 6066-82-6 |
| MF: | C4H5NO3 |
| MW: | 115.09 |
| EINECS: | 228-001-3 |
| Product Categories: | Zero-Length Crosslinker;heteroXlink;Coupling ReagentsSynthetic Reagents;Coupling;Others;APIS;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Succinimides;Peptide Synthesis;Supported Reagents;Supported Synthesis;Peptide coupling agents;Medical Intermediates;Heterocycles;Other Reagents;Miscellaneous Reagents;Synthetic Organic Chemistry;bc0001;6066-82-6 |
| Mol File: | 6066-82-6.mol |
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| N-Hydroxysuccinimide Chemical Properties |
| Melting point | 95-98 °C(lit.) |
| Boiling point | 215.33°C (rough estimate) |
| density | 1.4769 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.4080 (estimate) |
| storage temp. | Store at +2°C to +8°C. |
| solubility | DMSO (Soluble), Methanol (Slightly) |
| pka | 7.81±0.20(Predicted) |
| form | Liquid or Solid |
| color | Clear yellow-brown to brown |
| PH | 5-7 (50g/l, H2O, 20℃) |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| BRN | 113913 |
| Stability: | Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture. |
| InChIKey | NQTADLQHYWFPDB-UHFFFAOYSA-N |
| LogP | -2.01 |
| CAS DataBase Reference | 6066-82-6(CAS DataBase Reference) |
| NIST Chemistry Reference | N-hydroxylsuccinimide(6066-82-6) |
| EPA Substance Registry System | 2,5-Pyrrolidinedione, 1-hydroxy- (6066-82-6) |
| N-Hydroxysuccinimide Usage And Synthesis |
| Description | N-hydroxysuccinimide is a synthetic ingredient used in cosmetics as an ester to soften and condition skin. It's also a reagent, a substance used to trigger a reaction that leads to a new substance, such as peptides and polymers.
N-Hydroxysuccinimide is used in cosmetics and beauty products as an ester often seen in eye creams. N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. "Infra-orbital shadows are due to the accumulation of hemoglobin and its coloured degradation products - biliverdin, bilirubin and iron - in the dermis and epidermis ... N-hydroxysuccinimide renders the iron soluble for natural elimination" (source). |
| Chemical Properties | White to pale yellow |
| Uses | Reagent for preparation of active esters of amino acids. |
| Uses | N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings. |
| Uses | N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide. |
| Application | N-Hydroxysuccinimide has been used in the synthesis of intermediates such as:
N-succinimidyl 3-(di-tert-butylfluorosilyl)benzoate
4-[2,2-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester
N-succinimidyl 3-iodobenzoate
It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens.
Additive used in the carbodiimide method for improved amidations and peptide couplings.
N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid. |
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Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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