✨ Metoclopramide Monohydrochloride Monohydrate (CAS 54143-57-6) | USP/EP-Certified Gastroprokinetic & Antiemetic Agent ✨
🧪 Product Overview
Metoclopramide Monohydrochloride Monohydrate (CAS 54143-57-6) is a high-purity dopamine D2 receptor antagonist and prokinetic drug with the molecular formula C₁₄H₂₅Cl₂N₃O₃ and a molecular weight of 354.27. This white crystalline powder (purity ≥99%) is widely utilized to enhance gastrointestinal motility, prevent nausea/vomiting, and treat gastroparesis. It acts by accelerating gastric emptying and increasing lower esophageal sphincter pressure, achieving clinical effects within 15–30 minutes of administration12.
Key Functions:
Stimulates upper GI motility for conditions like gastroparesis.
Reduces chemotherapy-induced and postoperative vomiting.
Serves as a reference standard in pharmaceutical quality control.
Target Industries: Pharmaceutical manufacturing, hospitals, and clinical research.
⭐ Key Advantages
| 🔹 High Bioavailability | 🔹 Multi-Scenario Use | 🔹 Stability |
|---|
| ≥99% HPLC/EP-certified purity | Oral, IV, or IM administration | Stable under controlled humidity |
| Rapid onset (15–30 min) | Compatible with pediatric/adult dosing | Long shelf life (24 months) |
🏭 Applications
Gastrointestinal Disorders: Treatment of diabetic gastroparesis, reflux esophagitis, and functional dyspepsia.
Oncology Support: Management of chemotherapy-induced nausea and vomiting.
Postoperative Care: Prevention of delayed gastric emptying after surgery.
📊 Quality Assurance
Certifications: Complies with USP/EP pharmacopeial standards and ISO 9001
Testing: Validated via HPLC, NMR, and FTIR spectroscopy.
Packaging: Available in 25kg bulk drums or custom R&D batches (1g–10kg).
📈 Market Insights
The global gastrointestinal drugs market is projected to grow at 4.9% CAGR (2025–2030), driven by rising demand for antiemetics and prokinetics in chronic disease management. Metoclopramide remains a cost-effective first-line therapy, with Asia-Pacific leading production due to expanding generic drug manufacturing2.
China
