Basic information Safety Related Supplier

ChemicalBook Product Catalog L-Homocysteine thiolactone hydrochloride

1/1

L-Homocysteine thiolactone hydrochloride NEW

$44.00 25mg

$63.00 50mg

$89.00 100mg

Min. Order
Purity
Cas No31828-68-9
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

show more

Chemical Properties

Product Name	L-Homocysteine thiolactone hydrochloride
CAS No	31828-68-9
EC-No
Min. Order
Purity
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	L-Homocysteine thiolactone hydrochloride
Description	L-Homocysteine thiolactone hydrochloride is neurotoxic and can induce epilepsy and Alzheimer's disease.
In vitro	At a concentration of 0.25 mM and after 24 h incubation with L-Homocysteine thiolactone hydrochloride showed around 40% of cell death. Using 1 mM of L-Homocysteine thiolactone hydrochloride and after 24 h incubation up to 80% of cell death was detected. HUVEC cells were therefore incubated with increasing concentrations of Hcy (1 mM–10 mM) or L-Homocysteine thiolactone hydrochloride (0.25 mM–1 mM) for different times. None of the Hcy or L-Homocysteine thiolactone hydrochloride concentrations tested had an effect on TNF-α or IL-1α secretion. However, Hcy or L-Homocysteine thiolactone hydrochloride promoted the release of IL-8 starting from 3 h and increasing according to a dose-time dependent manner. [3]
In vivo	L-Homocysteine thiolactone hydrochloride dissolved in PBS was injected i.p., into 4-12-week-old mice (40-600 nmol/g body weight). To determine how Pon1 affects its turnover in vivo, L-Homocysteine thiolactone hydrochloride was injected i.p. into Pon1−/− and Pon1+/+ mice, and Hcy-thiolactone kinetics in plasma were monitored. A non-toxic dose of 600 nmol L-Homocysteine thiolactone hydrochloride /g body weight in most experiments, but similar results were obtained with doses as low as 40 nmol/g body weight. This shows that in Pon1−/− mice Hcy-thiolactone metabolism is not impaired during its transit from the intraperitoneal cavity to the bloodstream and suggests that Pon1 has a negligible contribution to Hcy-thiolactone turnover in membranes surrounding the intraperitoneal cavity. [4]
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : 20 mg/mL (130.18 mM), Sonication is recommended. DMSO : 100 mg/mL (650.91 mM), Sonication is recommended.
Keywords	LHomocysteine thiolactone hydrochloride \| L Homocysteine thiolactone hydrochloride \| L-Homocysteine thiolactone Hydrochloride

show more

Company Profile Introduction

You may like

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book