| Name | DL-Homocysteine thiolactone hydrochloride |
| Description | DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) is a cysteine derivative that binds to and induces conformational changes in various plasma proteins, slowing coagulation and inducing oxidative stress. It decreases left ventricular systolic blood pressure and cardiac force and induces seizures in vivo. |
| Cell Research | Only groups of hearts in which the CPP/CF relationship was studied twice in the absence of drugs were included in the study. After perfusion in the absence of any medication (control conditions), hearts were perfused with: 10?μM DL-Homocysteinethiolactone hydrochloride (DL-Hcy TLHC); 10?μM DL-Hcy TLHC + 30?μM L-NAME (N ω-Nitro-L-arginine methyl ester, an inhibitor of NOS); 10?μM DL-Hcy TLHC + 10?μM DL-PAG (DL-Propargylglycine, an inhibitor of cystathionine gamma lyase-CSE); 10?μM DL-Hcy TLHC + 10?μM ZnPPR IX (protoporphyrin IX zinc, an inhibitor of HO-1) and compared to the respective controls[1]. |
| In vitro | Acuted administration of DL-Homocysteinethiolactone hydrochloride (DL-Hcy TLHC) induces significant reduction of CF and partly of heart contractility, which confirms its cardiodepressive effect.?The simultaneous application of different inhibitors of important cardiovascular gasotransmitters with DL-Hcy TLHC shows that additional HO-1 inhibition induces more powerful effects than NOS or CSE inhibition.?The inhibition of CO production significantly increases DL-Hcy TLHC-induced effects on cardiodynamic parameters, while NOS and CSE inhibition only affects CF. Acuted administration of DL-Hcy TLHC and different gasotransmitter inhibitors does not show prooxidant potential[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (13.02 mM), Sonication is recommended.
DMSO : 25 mg/mL (162.73 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | Human Endogenous Metabolite | EndogenousMetabolite | Endogenous Metabolite | DL-Homocysteinethiolactone Hydrochloride | DL-Homocysteine thiolactone Hydrochloride | DLHomocysteine thiolactone hydrochloride | DL-Homocysteine thiolactone | DL Homocysteine thiolactone hydrochloride |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Ferroptosis Compound Library | Bioactive Compound Library | Natural Product Library | NO PAINS Compound Library | RO5 Drug-like Natural Product Library | Bioactive Compounds Library Max |
United States
