1. Product information
Names
| Name | (S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid |
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| Synonym | More Synonyms |
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H-Glu-OtBu Biological Activity
| Description | H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 |
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| Related Catalog | Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 326.8±32.0 °C at 760 mmHg |
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| Melting Point | 140ºC |
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| Molecular Formula | C9H17NO4 |
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| Molecular Weight | 203.236 |
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| Flash Point | 151.5±25.1 °C |
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| Exact Mass | 203.115753 |
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| PSA | 89.62000 |
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| LogP | 0.77 |
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| Appearance of Characters | Powder | White |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.476 |
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| Storage condition | Store at 0°C |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2922509090 |
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2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
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