What is IGF1-LR3
1. IGF-1 is basically a polypeptide hormone that has the same some of the same molecular properties as insulin. IGF dose actually stand for insulin-like growth factor. IGF-1 is mainly responsible for long bone growth in children and it also affects muscle growth and repair of adults.
2. Long R3 IGF-1 is a more potent version of IGF-1. It's chemically altered i like to think "enhanced" to prevent deactivation by IGF-1 binding proteins in the bloodstream. This results in a longer half-life of 20-30 hours instead of 20 min... So that means a far more effective version than the short chain we we re perhaps more familiar with.
IGF1-LR3 What does it do
1. IGF-1 LR3 greatly boosts muscle mass by inducing a state of muscle hyperplasia (increase in number of new muscle cells) in the MUSCLE WHERE ITS INJECTED! So think of it as muscle cell proliferation, or even the splitting of the cell so 1 becomes 2... That's why its perfect on cycle when you get increased muscle cell growth too. But why is IGF better than HGH The reason being is HGH causes IGF levels to rise in the liver first, then then the muscle, Whereas IGF-LR3 causes localized IGF levels to rocket.
2. Igf1-lr3 As you all know is the long acting version of Igf-1, Taking its active potential up towards 20 hours, But along with its ability to stimulate the growth of satellite muscle cells and helping them to mature into new muscle fibers it holds the ability to increase the uptake of many supplements we currently use, And it can cause the enhanced recovery of testicle size, and prevent muscle loss even in PCT. Plus another reason its so potent is because of the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF.. not so with this long acting version.
3. Here's a quote from one of the top research doctors in the world, Dr Sweeny the chairman of bioethics in 2002.H. Lee Sweeney, Ph.D., Professor and Chairman of Physiology at the University of Pennsylvania and a recognized expert on the subject of the genetic enhancement of skeletal muscle, spoke to the World Anti-Doping Association with regard to the muscle building and regenerating properties of IGF-1.
3. "Rats that were given IGF-1 and did nothing were bigger and stronger than rats that weren't given IGF-1 but exercised. And I'll bet you guessed that rats that were given IGF-1 and exercised were the biggest, strongest rats in the house. The positive effects of IGF-1 on the rats continued for months after the rats stopped getting the supplemental hormone, whereas the exercising rats immediately lost size and strength as soon as they stopped exercising."
4. In another study the muscle fibers of 27-month old rats - old age for rats - that were given IGF-1 during middle age, exhibited no deterioration of muscle fibers that indicate the classic and inevitable signs of aging. These rats did not lose any fast twitch muscle fibers - the fibers responsible for power and speed - and had the same speed and power output that they had when they were six months of age.
5. To quote Dr. Sweeney, "So we were able to conclude that IGF-1 could prevent all of the hallmarks of age-related atrophy and loss of skeletal muscle function in mammalian aging, at least based on the rodent model, and now we're hoping to pursue this in larger animal models
Application of recombinant human long-acting insulin-like growth factor rhIGF-1
Recombinant human long-chain insulin-like growth factor 1 (LR3-IGF1) is an analogue of insulin-like growth factor 1. Compared with IGF-1, LR3-IGF1 has 13 more amino acid chains (L) at the N-terminus, and the glutamic acid in the third position of IGF-1 is replaced by arginine (R3). Natural IGF-1 contains 70 amino acids (7.4KDa), while LR3-IGF1 contains 83 amino acids (9.11KDa). Both contain six cysteine residues and three pairs of disulfide bonds in a tertiary structure. The biological activity of LR3-IGF1 is 10 times higher than that of IGF-1; 200-1000 times higher than insulin. IGF-1LR3 is one of the most effective activators of the AKT signaling pathway. After activating the AKT signaling pathway, it stimulates cell growth and proliferation, and inhibits cell apoptosis. IGF-1LR3 adds 13 amino acids to the N-terminus of the intact IGF-1 molecule to form a long chain IGF-1 with 83 amino acids in the Chemicalbook, and replaces the third amino acid glutamic acid (E) of the IGF-1 molecule with arginine (R), hence the name R3. IGF-1LR3 has higher stability and biological activity compared to unmodified IGF-1.
Effect of recombinant human long-acting insulin-like growth factor rhIGF-1
1. Cytokines necessary for serum-free cell culture.
2. Promote bone growth and participate in wound healing.
3. Insulin antagonistic treatment of diabetes.
4. Myasthenia gravis.
5. Local use can promote the regeneration of injured sciatic nerves and can also be used to improve muscle production in the human body.
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