| Name | Hesperidin |
| Description | Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activity. |
| In vitro | METHODS: Tumor cells HeLa and HT-29 were treated with Hesperidin (20-100 µM) for 24-72 h. Cell viability was measured by MTT assay.
RESULTS: Treatment with Hesperidin significantly reduced cell viability and the effect of Hesperidin on cell viability was concentration and time dependent. Cells incubated with 100 µM Hesperidin for 72 h showed the greatest antiproliferative effect, with cell viability decreasing to 12% of control cells. [1]
METHODS: Human mesothelioma cells MSTO-211H were treated with Hesperidin (40-160 µM) for 48 h. Apoptosis was detected using DAPI and PI staining.
RESULTS: The percentage of sub-G1 phase increased from 20% to 35% in 40-160 µM Hesperidi-treated MSTO-211H cells. [2] |
| In vivo | METHODS: To assay antitumor activity in vivo, Hesperidin (200 mg/kg) was administered by gavage to BALB/c mice bearing CT-26 xenografts once daily for five days. Hesperidin was then administered as a single dose of cyclophosphamide (25 mg/kg) for fourteen days.
RESULTS: Leukocyte counts were increased in mice treated with Hesperidin prior to cyclophosphamide injection. This significant protective effect was observed 4 and 7 days after cyclophosphamide injection. In CT-26 tumor-bearing mice, co-administration of Hesperidin and cyclophosphamide significantly inhibited cyclophosphamide-induced delay in tumor growth. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (98.27 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 6 mg/mL (9.83 mM), suspension.In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Inhibitor | inhibit | inflammatory | Hesperidin | glycoside | flavanone | EndogenousMetabolite | Endogenous Metabolite | citrus | Autophagy | Apoptosis | antitumor | antioxidant | antiallergic |
| Inhibitors Related | Sucrose | Hydroxychloroquine | Daidzein | Guanidine hydrochloride | Fumaric acid | Tributyrin | Ferulic Acid | Formamide | Paeonol | Glycerol | Thymidine | 3-Indoleacetic acid |
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