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ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Pyridine derivatives Gimeracil

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Gimeracil NEW

$31.00 50mg

$54.00 100mg

$63.00 200mg

Min. Order
Purity99.86%
Cas No103766-25-2
Supply Ability10g
Update time2025-12-04

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP4Y

United States

United States

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Chemical Properties

Product Name	Gimeracil
CAS No	103766-25-2
EC-No
Min. Order
Purity	99.86%
Supply Ability	10g
Release date	2025/12/04

Product Introduction

Bioactivity

Name	Gimeracil
Description	Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.
Kinase Assay	Microdilution method: The culture media used are RPMI 1640 with glutamine, without bicarbonate and phenol red, buffered with morpholinopropanesulfonic acid (MOPS) (0.165 M, pH 7.0). Two-fold serial dilutions of Flucytosine (0.06-64 μg/mL) are prepared and dispensed in 50 uL aliquot, in flat-bottom 96-well assay plates which are kept frozen at -70 °C in sealed plastic bags until used. The inoculum is prepared spectrophotometrically and standardized to a concentration of 1.0-5.0 × 103 cfu per mL. A 50 μL volume of this suspension is used to inoculate each well containing 50 μL of the double concentration of Flucytosine to be tested. Once inoculated, each well therefore contains 100 μL of broth favoured over 200 μL to facilitate the agitation of the plates prior to spectrophotometric reading. After an incubation period of 24 and 48 hours at 35 °C, the plates are agitated for 3 minutes at 900 r.p.m. with a shaker and the optical density of the growth in each well is determined with the use of an automatic plate reader set at 495 nm. The inhibitory concentration of IC50 is computed mathematically.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (13.74 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 35 mg/mL (240.48 mM), Sonication is recommended.
Keywords	repair \| radiotherapy \| PAN-4 \| Lu-99 \| LC-11 \| KB/C3 \| Inhibitor \| inhibit \| Gimeracil \| DNA \| DHPS
Inhibitors Related	Stavudine \| Aceglutamide \| Cysteamine hydrochloride \| Sodium 4-phenylbutyrate \| Hydroxychloroquine \| Guanidine hydrochloride \| Adenine \| Paeonol \| Sodium butanoate \| Thymidine \| Naringin \| Alginic acid
Related Compound Libraries	Failed Clinical Trials Compound Library \| Anti-Pancreatic Cancer Compound Library \| Bioactive Compound Library \| EMA Approved Drug Library \| Anti-Breast Cancer Compound Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Anti-Cancer Approved Drug Library \| Bioactive Compounds Library Max \| Anti-Cancer Drug Library \| Anti-Cancer Active Compound Library

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